Total hydroperoxide and biological antioxidant potentials in a neonatal sepsis model

Hiroki Kakita, Mohamed H. Hussein, Ghada A. Daoud, Takenori Kato, Hiroki Murai, Takahiro Sugiura, Keisuke Mizuno, Yasumasa Yamada, Tetsuya Ito, Sumio Fukuda, Ineko Kato, Satoshi Suzuki, Hajime Togari

研究成果: Article査読

32 被引用数 (Scopus)

抄録

Oxidant/antioxidant imbalance plays an important role in septic shock. The present study examined changes in circulating oxidative components in a neonatal sepsis model. Subjects were 14 newborn mixed-strain piglets randomly divided into two groups: a cecal ligation and perforation (CLP) model (n = 7) and sham (n = 7). Blood samples for total hydroperoxide (TH), biological antioxidant potential (BAP), tumor necrosis factor (TNF) α, interleukin (IL)-6, and IL-10 were collected pre-CLP and at 1, 3, and 6 h post-CLP. TH and BAP levels at 1 h post-CLP were significantly higher in the CLP group than in the sham group. In the CLP group, TH decreased gradually and reached baseline levels by 6 h post-CLP, while BAP remained elevated. Linear correlations were identified between serum TH and BAP at 1 h post-CLP, serum TH and TNF-α at 1 h post-CLP, and BAP and IL-6 at 6 h post-CLP. Changes in and correlations between circulating oxidative and inflammatory state components in a neonatal sepsis model were clarified. This is the first study to reveal that the presence of oxidant/antioxidant imbalance in sepsis and septic shock changes during the disease course.

本文言語English
ページ(範囲)675-679
ページ数5
ジャーナルPediatric Research
60
6
DOI
出版ステータスPublished - 12-2006
外部発表はい

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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