Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

FANTOM Consortium

研究成果: Article査読

312 被引用数 (Scopus)

抄録

Although it is generally accepted that cellular differentiation requires changes to transcriptional networks, dynamic regulation of promoters and enhancers at specific sets of genes has not been previously studied en masse. Exploiting the fact that active promoters and enhancers are transcribed, we simultaneously measured their activity in 19 human and 14 mouse time courses covering a wide range of cell types and biological stimuli. Enhancer RNAs, then messenger RNAs encoding transcription factors, dominated the earliest responses. Binding sites for key lineage transcription factors were simultaneously overrepresented in enhancers and promoters active in each cellular system. Our data support a highly generalizable model in which enhancer transcription is the earliest event in successive waves of transcriptional change during cellular differentiation or activation.

本文言語English
ページ(範囲)1010-1014
ページ数5
ジャーナルScience
347
6225
DOI
出版ステータスPublished - 27-02-2015

All Science Journal Classification (ASJC) codes

  • 一般

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