Transcriptomic profiling predicts multiple pathways and molecules associated with the metastatic phenotype of oral cancer cells

Yuka Ideta, Takanobu Tagawa, Yuichiro Hayashi, Junichi Baba, Kimiko Takahashi, Kenji Mitsudo, Kouhei Sakurai

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Background/Aim: Metastasis to cervical lymph nodes of oral squamous cell carcinoma (OSCC) leads to a poor prognosis. The present study aimed at investigating the pathways and molecules associated with OSCC metastasis. Materials and Methods: The transcriptome between HSC-3 cells and their highly metastatic subline, HSC-3-M3 cells, was examined using gene expression microarray. Gene enrichment analyses and Ingenuity Pathway Analysis were performed. Kaplan-Meier plot analysis using a publicly available dataset was conducted to assess whether candidate molecules are prognosticators. Results: A total of 1,018 genes were differentially expressed, and the inflammatory pathway and NF-κB were predicted to be activated in HSC-3-M3 cells. CSF2 was suggested to be an indicator of poor prognosis in head and neck cancers. Conclusion: Inflammation and NF-κB may be involved in the metastasis of OSCC, and CSF2 is a promising diagnostic and therapeutic molecule. Moreover, HSC-3-M3 cells are a useful cell line model for studying OSCC progression.

本文言語English
ページ(範囲)17-27
ページ数11
ジャーナルCancer Genomics and Proteomics
18
1
DOI
出版ステータスPublished - 01-2021
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学
  • 遺伝学
  • 癌研究

フィンガープリント

「Transcriptomic profiling predicts multiple pathways and molecules associated with the metastatic phenotype of oral cancer cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル