TY - JOUR
T1 - Transformation of radial glia into postnatal neural stem cells depends on birth
AU - Takemura, Shoko
AU - Kawase, Koya
AU - Wolbeck, Laura
AU - Nakamura, Yasuhisa
AU - Matsumoto, Mami
AU - Jinnou, Hideo
AU - Tahara, Aika
AU - Sawada, Masato
AU - Kubota, Yoshiaki
AU - Herranz-Pérez, Vicente
AU - García-Verdugo, José Manuel
AU - Ishibashi, Nobuyuki
AU - Gallo, Vittorio
AU - Ohno, Nobuhiko
AU - Khodosevich, Konstantin
AU - Sawamoto, Kazunobu
N1 - Publisher Copyright:
© 2025 The Author(s)
PY - 2025/8/26
Y1 - 2025/8/26
N2 - A common feature of various postnatal stem cells is their close association with blood vessels. Postnatal neural stem cells (NSCs) in the ventricular-subventricular zone originate from fetal radial glia (RG), which possess NSC properties. Here, using live imaging and three-dimensional (3D) electron microscopy, we investigated how RG convert into postnatal NSCs and characterized the fine 3D morphology of the ventricular-subventricular zone. We found that preterm birth disrupts RG-endothelial cell interactions during this transformation, impairing both the structure and stemness of adult NSCs. These findings underscore the importance of a birth-dependent transformation. Our results indicate that RG fiber transection, which depends on the birth process, and endfoot formation on blood vessels, which depends on birth timing, are both critical steps in the conversion of RG into adult NSCs.
AB - A common feature of various postnatal stem cells is their close association with blood vessels. Postnatal neural stem cells (NSCs) in the ventricular-subventricular zone originate from fetal radial glia (RG), which possess NSC properties. Here, using live imaging and three-dimensional (3D) electron microscopy, we investigated how RG convert into postnatal NSCs and characterized the fine 3D morphology of the ventricular-subventricular zone. We found that preterm birth disrupts RG-endothelial cell interactions during this transformation, impairing both the structure and stemness of adult NSCs. These findings underscore the importance of a birth-dependent transformation. Our results indicate that RG fiber transection, which depends on the birth process, and endfoot formation on blood vessels, which depends on birth timing, are both critical steps in the conversion of RG into adult NSCs.
KW - CP: Developmental biology
KW - CP: Stem cell research
KW - birth
KW - development
KW - neural stem cells
KW - radial glia
UR - https://www.scopus.com/pages/publications/105011729178
UR - https://www.scopus.com/pages/publications/105011729178#tab=citedBy
U2 - 10.1016/j.celrep.2025.116029
DO - 10.1016/j.celrep.2025.116029
M3 - Article
C2 - 40713958
AN - SCOPUS:105011729178
SN - 2639-1856
VL - 44
JO - Cell Reports
JF - Cell Reports
IS - 8
M1 - 116029
ER -