Transformed Follicular Lymphoma (TFL) predicts outcome in advanced endometrial cancer

Senn Wakahashi, Fumi Kawakami, Kanako Wakahashi, Kentaro Minagawa, Keitaro Matsuo, Yoshio Katayama, Hideto Yamada, Toshimitsu Matsui, Tamotsu Sudo

研究成果: ジャーナルへの寄稿学術論文査読

6 被引用数 (Scopus)

抄録

Background: Transformed follicular lymphoma (TFL, ZC3H12D) was identified as a candidate tumor suppressor gene that contributes to cell-cycle arrest through regulation of Rb phosphorylation, but the clinical impact of TFL is unknown. The goal of this study was to evaluate the prognostic significance of TFL expression in advanced endometrial cancer. Methods: Tissue samples were obtained from 103 patients with Federation Internationale des Gynaecologistes et Obstetristes stage III–IV endometrial cancer. Associations between TFL expression and outcomes were evaluated using the Kaplan–Meier method and multivariate Cox proportional hazards regression models. Results: There were 24 TFL-low cases (23.3%) and the 10-year progression-free survival (PFS) and overall survival (OS) in these cases were lower than those for patients with normal TFL expression in univariate analysis (PFS, P ¼ 0.003; OS, P ¼ 0.106). In multivariate analysis, TFL status was a significant predictor for PFS [HR ¼ 2.76; 95% confidence interval (CI), 1.45–5.28; P ¼ 0.002] and OS (HR ¼ 1.94; 95% CI, 0.91–4.11; P ¼ 0.085), adjusted for covariates. The TFL gene maps to human chromosome 6q25.1, where estrogen receptor alpha (ERa) gene ESR1 is also located. Lack of ERa expression is a poor prognostic factor in early endometrial cancer. Among 41 ERa-low patients, 10-year PFS was significantly lower in 15 TFL-low cases (univariate analysis, P ¼ 0.055; multivariate analysis, HR ¼ 4.70; 95% CI, 1.68–13.20; P ¼ 0.003). Conclusions: We identified TFL as a strong independent prognostic factor, regardless of ERa status. Impact: An investigation of the mechanism underlying tumor suppression by TFL may lead to new therapies for patients with advanced endometrial cancer.

本文言語英語
ページ(範囲)963-969
ページ数7
ジャーナルCancer Epidemiology Biomarkers and Prevention
27
8
DOI
出版ステータス出版済み - 08-2018
外部発表はい

All Science Journal Classification (ASJC) codes

  • 医学一般

フィンガープリント

「Transformed Follicular Lymphoma (TFL) predicts outcome in advanced endometrial cancer」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル