Transgenic mouse model for skin malignant melanoma

Masashi Kato, Masahide Takahashi, Anwarul A. Akhand, Wei Liu, Yan Dai, Satoru Shimizu, Takashi Iwamoto, Haruhiko Suzuki, Izumi Nakashima

研究成果: Article査読

166 被引用数 (Scopus)

抄録

We report here on a novel metallothionein-I (MT)/ret transgenic mouse line in which skin melanosis, benign melanocytic tumor and malignant melanoma metastasizing to distant organs develop stepwise. The process of tumor development and its malignant transformation in this line may resemble that of the human giant congenital melanocytic nevus that is present at birth and that frequently gives rise to malignant melanoma during aging. We observed an increase in the expression level and activity of the ret transgene during the disease progression. That increase in transgene expression accompanied an activation of mitogen-activated protein kinases (MAPKs) and c-Jun as well as matrix metalloproteinases. These results suggest that progressive dysregulation of the expression level of the ret transgene might play a crucial role in the malignant transformation of melanocytic tumors developed in the MT/ret transgenic mouse line.

本文言語English
ページ(範囲)1885-1888
ページ数4
ジャーナルOncogene
17
14
DOI
出版ステータスPublished - 08-10-1998
外部発表はい

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

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