Transient activation of Notch signaling in the injured adult brain

Kouko Tatsumi, Hiroaki Okuda, Manabu Makinodan, Takahira Yamauchi, Eri Makinodan, Hiroko Matsuyoshi, Takayuki Manabe, Akio Wanaka

研究成果: ジャーナルへの寄稿学術論文査読

18 被引用数 (Scopus)

抄録

Brain injury induces various kinds of cellular responses that lead to tissue regeneration and repair. Recent studies have demonstrated that resident progenitors proliferate and then differentiate into mature neuronal cells. We show here that proliferating cells in the cryo-injured cerebral cortex transiently expressed Notch1 immunoreactivity in their cytoplasm. Since activated Notch signaling regulates cellular fate in the developing nervous system, similar regulation may exist in the injured adult brain. To monitor the Notch signaling pathway, we examined whether components of the signaling pathway were co-expressed in Notch1-positive cells. Presenilin-1, a membrane-spanning protease that is required for the release of the Notch intracellular domain, was detected in the Notch1-positive cells and Hes1, a target of the Notch intracellular domain, also co-localized with Notch1 three days after cryo-injury. These results suggest that transient activity of the Notch signaling pathway is involved in the regulation of proliferation and differentiation of progenitors in the injured brain.

本文言語英語
ページ(範囲)15-19
ページ数5
ジャーナルJournal of Chemical Neuroanatomy
39
1
DOI
出版ステータス出版済み - 01-2010
外部発表はい

All Science Journal Classification (ASJC) codes

  • 細胞および分子神経科学

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