Transient hyper-17-OHPnemia unrelated to cross-reactions with residual fetal adrenal cortex products

Haruo Mizuno, Yoichiro Ohro, Yukari Sugiyama, Tetsuya Ito, Tomonobu Hasegawa, Keiko Homma, Hajime Ueshiba, Makoto Ono, Hajime Togari

研究成果: ジャーナルへの寄稿学術論文査読

3 被引用数 (Scopus)

抄録

Objective: To clarify the pathogenesis of transient hyper-17α- hydroxyprogesteronemia, we initiated a laboratory investigation in a pre-term infant with persistently high serum 17α-hydroxyprogesterone (17-OHP) until 2 months of age. Methods: Serum 17-OHP level was measured by high-performance liquid chromatography and radioimmunoassay, and gene analysis of CYP21A2 (21-hydroxylase) was performed. Result: Serum 17-OHP level on the 29th day of life was 25.4 ng/ml, and the urinary steroid profile showed low pregnanetriolone. Gene analysis of 21-hydroxylase disclosed no mutation, and 17-OHP normalized by 3 months of age without specific treatment. Conclusion: Transient elevations in 17-OHP, which do not appear related to cross-reactions with products of a residual fetal adrenal cortex, may occur in the first few months of life.

本文言語英語
ページ(範囲)242-245
ページ数4
ジャーナルHormone Research
61
5
DOI
出版ステータス出版済み - 2004
外部発表はい

All Science Journal Classification (ASJC) codes

  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

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