抄録
Objective: To clarify the pathogenesis of transient hyper-17α- hydroxyprogesteronemia, we initiated a laboratory investigation in a pre-term infant with persistently high serum 17α-hydroxyprogesterone (17-OHP) until 2 months of age. Methods: Serum 17-OHP level was measured by high-performance liquid chromatography and radioimmunoassay, and gene analysis of CYP21A2 (21-hydroxylase) was performed. Result: Serum 17-OHP level on the 29th day of life was 25.4 ng/ml, and the urinary steroid profile showed low pregnanetriolone. Gene analysis of 21-hydroxylase disclosed no mutation, and 17-OHP normalized by 3 months of age without specific treatment. Conclusion: Transient elevations in 17-OHP, which do not appear related to cross-reactions with products of a residual fetal adrenal cortex, may occur in the first few months of life.
本文言語 | 英語 |
---|---|
ページ(範囲) | 242-245 |
ページ数 | 4 |
ジャーナル | Hormone Research |
巻 | 61 |
号 | 5 |
DOI | |
出版ステータス | 出版済み - 2004 |
外部発表 | はい |
All Science Journal Classification (ASJC) codes
- 内分泌学、糖尿病および代謝内科学
- 内分泌学