Transient pancytopenia associated with parvovirus infection in a healthy child

Yasuto Kondo, Michiko Kakami, Hiroshi Kawaguchi, Fumi Miyake, Atsuo Urisu, Yoshizo Asano, Seiji Kojima

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Human parvovirus (HPV) B19 infection has been reported to be a cause of transient erythroblastopenia in patients with hemolytic disorders (aplastic crisis). Human parvovirus B19 is directly cytotoxic for erythroid progenitor cells and inhibits erythropoiesis. Infrequently, HPV B19 inhibits hematopoiesis of three cell lineages and causes transient pancytopenia in patients with hemolytic disorders. In experimental infections with normal volunteers, reticulocytes and platelet counts in the peripheral blood decreased 10-14 days after intranasal inoculation, and these hematological abnormalities recovered spontaneously within a few weeks. We report a boy without any underlying disease who developed transient pancytopenia. A HPV B19 infection was confirmed by serological studies and DNA analysis as the causative infectious agent associated with severe pancytopenia.

本文言語English
ページ(範囲)695-697
ページ数3
ジャーナルPediatrics International
44
6
DOI
出版ステータスPublished - 30-11-2002

All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康

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