Translational Research Using Carbohydrate Mimetic Peptides

Michiko N. Fukuda, Kazuhiro Sugihara

研究成果: Chapter

抄録

In the era of translational research, carbohydrate-based drug discovery has yet to be explored. This is due in large part to our inability to undertake automated chemical synthesis of complex carbohydrates. This dilemma can be partially, if not totally, circumvented by using carbohydrate mimetic peptides, which can be identified from peptide-displaying phage library. In this approach, a phage clone displaying a short peptide that mimics part of the conformation of specific carbohydrate structure is selected by screening a peptide-displaying phage library using anti-carbohydrate antibody or lectin as target. Chemically synthesized peptides function as ligands for carbohydrate-binding proteins in vitro and in vivo. Peptides can also serve as immunogens to raise anti-carbohydrate antibodies in vivo in animals. This chapter provides examples of successful application of peptide-displaying phage technology to drug discovery. These approaches should benefit translational research by supplying carbohydrate mimetic peptides as diagnostics and therapeutics.

本文言語English
ホスト出版物のタイトルGlycoscience
ホスト出版物のサブタイトルBiology and Medicine
出版社Springer Japan
ページ1523-1528
ページ数6
ISBN(電子版)9784431548416
ISBN(印刷版)9784431548409
DOI
出版ステータスPublished - 01-01-2015
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)
  • 医学(全般)

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