Transmission of NDM-5-Producing and OXA-48-Producing Escherichia coli Sequence Type 648 by International Visitors without Previous Medical Exposure

Sohei Harada, Masahiro Suzuki, Toshiharu Sasaki, Aki Sakurai, Masato Inaba, Hosoda Takuya, Mitsutaka Wakuda, Yohei Doi

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Carbapenemase-producing Escherichia coli sequence type (ST) 648 strains were isolated from two international visitors without previous medical exposure from Southeast Asian countries in a hospital in Japan. One isolate, FUJ80154, carried blaNDM-5 in a complex class 1 integron on an IncFIB/FII plasmid; the other isolate, FUJ80155, carried two copies of blaOXA-48 on the chromosome flanked by IS1R on both sides. The core-genome based-phylogenetic analysis with publicly available genome data of E. coli ST648 carrying blaNDM-5 or blaOXA-48-like demonstrated high genetic similarity between FUJ80154 and NDM-5-prooducing E. coli ST648 strains isolated in South and Southeast Asian countries. On the other hand, no closely related isolates of FUJ80155 were identified. In the absence of prior hospitalization overseas, neither patient had qualified for routine screening of multidrug-resistant organisms, and the isolates were incidentally identified in cultures ordered at the discretion of the treating physician.

本文言語English
論文番号e01827-21
ジャーナルMicrobiology spectrum
9
3
DOI
出版ステータスPublished - 12-2021

All Science Journal Classification (ASJC) codes

  • 生理学
  • 生態学
  • 免疫学および微生物学(全般)
  • 遺伝学
  • 微生物学(医療)
  • 細胞生物学
  • 感染症

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