Treatment for non-clear cell renal cell carcinomab

研究成果: Chapter

1 被引用数 (Scopus)

抄録

Non-clear cell (NCC) renal cell carcinoma (RCC) is less common and accounts for 25 % of all patients with metastatic RCC. Metastatic NCCRCC and clear cell (CC) RCC both respond infrequently to cytotoxic and cytokine therapy; however, compared with CCRCC patients, NCCRCC patients have a poorer prognosis. Tyrosine kinase inhibitors (TKIs) such as sorafenib and sunitinib have significant activity in metastatic NCCRCC, but the efficacy of each agent seems to vary between different NCCRCC forms. Preliminary clinical data for temsirolimus, one of the mammalian targets of rapamycin (mTOR) inhibitors, appear to be promising, but future phase III trials should include patients with RCCs with NCC histology as well as CCRCC, with appropriate stratification to take the balance between each treatment arm. Many ongoing phase II trials should provide interesting preliminary insights into the antitumor efficacy of particular agents in these tumors. These approaches will lead us to improvements in the management of NCCRCC so as we have already achieved with the more common CCRCC.

本文言語English
ホスト出版物のタイトルRenal Cell Carcinoma
ホスト出版物のサブタイトルMolecular Features and Treatment Updates
出版社Springer Japan
ページ319-332
ページ数14
ISBN(電子版)9784431555315
ISBN(印刷版)9784431555308
DOI
出版ステータスPublished - 01-01-2017
外部発表はい

All Science Journal Classification (ASJC) codes

  • 医学(全般)
  • 生化学、遺伝学、分子生物学(全般)

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