Treatment of carbon tetrachloride and phenobarbital-induced chronic liver failure with intrasplenic hepatocyte transplantation

Naoya Kobayashi, Masahiro Ito, Junta Nakamura, Jin Cai, James M. Hammel, Ira J. Fox

研究成果: Article査読

28 被引用数 (Scopus)

抄録

Hepatocyte transplantation (HTx) has been shown to improve the survival of laboratory animals with experimentally induced acute liver failure and to ameliorate the physiologic abnormalities associated with liver-based metabolic deficiencies. However, the role of HTx in the treatment of liver cirrhosis (LC) has not been adequately studied. In order to address this issue, HTx was performed in rats following induction of stable LC using phenobarbital (PhB) and carbon tetrachloride (CCl4). Intrasplenic transplantation of 50 x 106 primary hepatocytes could significantly improve liver functions and prolong the survival of rats with irreversible, decompensated LC.

本文言語English
ページ(範囲)671-673
ページ数3
ジャーナルCell Transplantation
9
5
DOI
出版ステータスPublished - 01-01-2000
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Cell Biology
  • Transplantation

フィンガープリント 「Treatment of carbon tetrachloride and phenobarbital-induced chronic liver failure with intrasplenic hepatocyte transplantation」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル