TY - JOUR
T1 - Treatment outcomes of local advanced external auditory canal squamous cell carcinomas
AU - Kano, Satoshi
AU - Morita, Shinya
AU - Nakamaru, Yuji
AU - Mizumachi, Takatsugu
AU - Tsushima, Nayuta
AU - Suzuki, Takayoshi
AU - Nakazono, Akira
AU - Fukuda, Atsushi
AU - Yasuda, Koichi
AU - Onimaru, Rikiya
AU - Shirato, Hiroki
AU - Homma, Akihiro
N1 - Publisher Copyright:
© 2019, Japan Society for Head and Neck Cancer. All rights reserved.
PY - 2019
Y1 - 2019
N2 - We analyzed the treatment outcomes and safety of concomitant chemoradiotherapy (CCRT), especially with a combination of docetaxel, cisplatin and 5FU (TPF), for local advanced external auditory canal squamous cell carcinomas. In addition, we analyzed the correlation between tumor invasion site and prognosis. The study comprised 21 patients with the following criteria: (1) external auditory canal squamous cell carcinomas which were subject to radical treatment at Hokkaido University Hospital between 2007 and 2017, and (2) T3–4 classified according to the University of Pittsburg system. As a result, tumor invasion into the dura or temporomandibular joint was associated with neck lymph node metastasis, and tumor invasion into the temporomandibular joint was associated with local recurrence. The 2-year overall survival rate (OS) and 2-year local control rate (LC) were 61.1％ and 52.1％ in all patients, respectively. In patients treated with CCRT, the 2-year OS was 85.7％ in CCRT with TPF and 25.0％ in CCRT with others, and the 2-year LC was 57.1％ in CCRT with TPF and 25.0％ in CCRT with others. Grade 3︲4 leucopenia and neutropenia occurred in 55％ and 45％ of patients treated with CCRT with TPF, respectively. CCRT with TPF shows high efficacy and safety for local advanced external auditory canal squamous cell carcinomas.
AB - We analyzed the treatment outcomes and safety of concomitant chemoradiotherapy (CCRT), especially with a combination of docetaxel, cisplatin and 5FU (TPF), for local advanced external auditory canal squamous cell carcinomas. In addition, we analyzed the correlation between tumor invasion site and prognosis. The study comprised 21 patients with the following criteria: (1) external auditory canal squamous cell carcinomas which were subject to radical treatment at Hokkaido University Hospital between 2007 and 2017, and (2) T3–4 classified according to the University of Pittsburg system. As a result, tumor invasion into the dura or temporomandibular joint was associated with neck lymph node metastasis, and tumor invasion into the temporomandibular joint was associated with local recurrence. The 2-year overall survival rate (OS) and 2-year local control rate (LC) were 61.1％ and 52.1％ in all patients, respectively. In patients treated with CCRT, the 2-year OS was 85.7％ in CCRT with TPF and 25.0％ in CCRT with others, and the 2-year LC was 57.1％ in CCRT with TPF and 25.0％ in CCRT with others. Grade 3︲4 leucopenia and neutropenia occurred in 55％ and 45％ of patients treated with CCRT with TPF, respectively. CCRT with TPF shows high efficacy and safety for local advanced external auditory canal squamous cell carcinomas.
KW - CCRT
KW - External auditory canal carcinoma
KW - TPF
UR - https://www.scopus.com/pages/publications/85075026517
UR - https://www.scopus.com/pages/publications/85075026517#tab=citedBy
U2 - 10.5981/jjhnc.45.300
DO - 10.5981/jjhnc.45.300
M3 - Article
AN - SCOPUS:85075026517
SN - 1349-5747
VL - 45
SP - 300
EP - 304
JO - Japanese Journal of Head and Neck Cancer
JF - Japanese Journal of Head and Neck Cancer
IS - 3
ER -