Treatment with a Gamma-Secretase Inhibitor Promotes Functional Recovery in Human iPSC- Derived Transplants for Chronic Spinal Cord Injury

Toshiki Okubo; Narihito Nagoshi; Jun Kohyama; Osahiko Tsuji; Munehisa Shinozaki; Shinsuke Shibata; Yoshitaka Kase; Morio Matsumoto; Masaya Nakamura; Hideyuki Okano

doi:10.1016/j.stemcr.2018.10.022

Treatment with a Gamma-Secretase Inhibitor Promotes Functional Recovery in Human iPSC- Derived Transplants for Chronic Spinal Cord Injury

Toshiki Okubo
, Narihito Nagoshi
, Jun Kohyama
, Osahiko Tsuji
, Munehisa Shinozaki
, Shinsuke Shibata
, Yoshitaka Kase
, Morio Matsumoto
, Masaya Nakamura
, Hideyuki Okano

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

79 被引用数 (Scopus)

抄録

In this article, Okano and colleagues show that the GSI-treated hiPSC-NS/PCs caused significantly enhanced axonal regrowth, remyelination, inhibitory synapse formation with the host neural circuitry, and reticulo spinal tract fiber formation. These favorable outcomes contributed to motor function improvement. Therefore, treating cells with GSI provides a beneficial effect after transplantation, even in the chronic phase following SCI.

本文言語	英語
ページ（範囲）	1416-1432
ページ数	17
ジャーナル	Stem Cell Reports
巻	11
号	6
DOI	https://doi.org/10.1016/j.stemcr.2018.10.022
出版ステータス	出版済み - 11-12-2018
外部発表	はい

All Science Journal Classification (ASJC) codes

生化学
遺伝学
発生生物学
細胞生物学

文献へのアクセス

10.1016/j.stemcr.2018.10.022

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引用スタイル

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AU - Tsuji, Osahiko

AU - Shinozaki, Munehisa

AU - Shibata, Shinsuke

AU - Kase, Yoshitaka

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AU - Nakamura, Masaya

AU - Okano, Hideyuki

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KW - axonal regrowth

KW - chronic spinal cord injury

KW - gamma-secretase inhibitor

KW - iPS cell

KW - motor function

KW - p38 MAPK

KW - regenerative medicine

KW - transplantation

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