Trefoil factor 3 (TFF3): A promising indicator for diagnosing thyroid follicular carcinoma

Toru Takano, Hiroya Yamada

研究成果: Review article

14 引用 (Scopus)

抄録

Since the introduction of fine needle aspiration biopsy (FNAB) in the 1970's, a preoperative diagnostic technique for thyroid follicular carcinoma has long been awaited. Many markers that distinguish follicular carcinomas from adenomas have been reported; however, most of them have not been confirmed to be beneficial for clinical use. Trefoil factor 3 (TFF3) is a relatively new family of peptides that bears the three-loop trefoil domain. Several groups have reported that the suppression of TFF3 mRNA expression is related to malignant characteristics of thyroid follicular cell- derived tumors and the expression level of TFF3 mRNA is the most promising indicator for diagnosing follicular carcinoma. Development of 7F.F.3-based diagnostic methods is now ongoing and it may not be long before thyroid follicular carcinoma can be diagnosed preoperatively using an aspirated sample from the tumor.

元の言語English
ページ(範囲)9-16
ページ数8
ジャーナルEndocrine Journal
56
発行部数1
DOI
出版物ステータスPublished - 24-03-2009

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Follicular Adenocarcinoma
Carcinoma
Messenger RNA
Fine Needle Biopsy
Adenoma
Neoplasms
Peptides
Trefoil Factor-3

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

これを引用

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Trefoil factor 3 (TFF3) : A promising indicator for diagnosing thyroid follicular carcinoma. / Takano, Toru; Yamada, Hiroya.

:: Endocrine Journal, 巻 56, 番号 1, 24.03.2009, p. 9-16.

研究成果: Review article

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