Trial to produce animal model of Alzheimer's disease by continuous infusion of β-amyloid protein into the rat cerebral ventricle

T. Nabeshima

研究成果: Review article査読

4 被引用数 (Scopus)

抄録

To develop an animal model of Alzheimer's disease, we investigated the toxicity of β-amyloid protein which is a component of senile plaques in Alzheimer's disease. β-Amyloid was infused into the cerebral ventricle of rats for 14 days using a mini-osmotic pump. The performance of habituation, water maze and passive avoidance tasks in β-amyloid protein treated rats was impaired. Choline acetyltransferase activity significantly decreased in the hippocampus both immediately and 2 weeks after cessation of the infusion. However, the learning impairment is recoverable 2 weeks after cessation of the infusion. Both immediately and 2 weeks after cessation of the infusion, glial fibrillary acidic protein immunoreactivity increased. Further, β- amyloid protein altered the staining of nuclei of cells in the hippocampus only 2 weeks after cessation. These results suggest that β-amyloid protein damages the central nervous system in vivo, and that this animal could be used as a model of Alzheimer's disease.

本文言語English
ページ(範囲)411-418
ページ数8
ジャーナルJapanese Journal of Psychopharmacology
15
5
出版ステータスPublished - 01-01-1995
外部発表はい

All Science Journal Classification (ASJC) codes

  • 医学(全般)

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