Trophinin in cell adhesion and signal transduction

Michiko N. Fukuda, Kazuhiro Sugihara

研究成果: Article査読

13 被引用数 (Scopus)

抄録

The process of human embryo implantation is mediated not only by evolutionarily conserved mechanisms but by activities unique to humans. Among the latter, evidence suggests that the cell adhesion molecule trophinin plays a unique role in human embryo implantation. Here, we describe characteristics of trophinin protein and of the trophinin-associated proteins bystin and tastin. We then describe trophinin-mediated signal transduction in trophectoderm cells during human embryo implantation and events related to human sperm tail motility. We also report dual roles for trophinin in human cancers in terms of promoting malignancy in some tumor types and suppressing it in others.

本文言語English
ページ(範囲)342-350
ページ数9
ジャーナルFrontiers in Bioscience - Elite
4 E
1
DOI
出版ステータスPublished - 01-01-2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)
  • 免疫学および微生物学(全般)

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