Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism

Atsushi Shimohata, Keiichi Ishihara, Satoko Takai, Hiroyuki Miyamoto, Hiromasa Morishita, Guy Ornthanalai, Matthieu Raveau, Abdul Shukkur Ebrahim, Kenji Amano, Kazuyuki Yamada, Haruhiko Sago, Satoshi Akiba, Nobuko Mataga, Niall P. Murphy, Tsuyoshi Miyakawa, Kazuhiro Yamakawa

研究成果: Article

8 引用 (Scopus)

抄録

Ts1Cje mice have a segmental trisomy of chromosome 16 that is orthologous to human chromosome 21 and display Down syndrome-like cognitive impairments. Despite the occurrence of affective and emotional impairments in patients with Down syndrome, these parameters are poorly documented in Down syndrome mouse models, including Ts1Cje mice. Here, we conducted comprehensive behavioral analyses, including anxiety-, sociability-, and depression-related tasks, and biochemical analyses of monoamines and their metabolites in Ts1Cje mice. Ts1Cje mice showed enhanced locomotor activity in novel environments and increased social contact with unfamiliar partners when compared with wild-type littermates, but a significantly lower activity in familiar environments. Ts1Cje mice also exhibited some signs of decreased depression like-behavior. Furthermore, Ts1Cje mice showed monoamine abnormalities, including increased extracellular dopamine and serotonin, and enhanced catabolism in the striatum and ventral forebrain. This study constitutes the first report of deviated monoamine metabolism that may help explain the basis for abnormal behaviors, including the environmental stimuli-triggered hyperactivity, increased sociability and decreased depression-like behavior in Ts1Cje mice.

元の言語English
ページ(範囲)1-12
ページ数12
ジャーナルExperimental Neurology
293
DOI
出版物ステータスPublished - 01-07-2017

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Down Syndrome
Dopamine
Serotonin
Depression
Chromosomes, Human, Pair 21
Social Environment
Human Chromosomes
Locomotion
Prosencephalon
Anxiety

All Science Journal Classification (ASJC) codes

  • Neurology
  • Developmental Neuroscience

これを引用

Shimohata, Atsushi ; Ishihara, Keiichi ; Takai, Satoko ; Miyamoto, Hiroyuki ; Morishita, Hiromasa ; Ornthanalai, Guy ; Raveau, Matthieu ; Ebrahim, Abdul Shukkur ; Amano, Kenji ; Yamada, Kazuyuki ; Sago, Haruhiko ; Akiba, Satoshi ; Mataga, Nobuko ; Murphy, Niall P. ; Miyakawa, Tsuyoshi ; Yamakawa, Kazuhiro. / Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism. :: Experimental Neurology. 2017 ; 巻 293. pp. 1-12.
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title = "Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism",
abstract = "Ts1Cje mice have a segmental trisomy of chromosome 16 that is orthologous to human chromosome 21 and display Down syndrome-like cognitive impairments. Despite the occurrence of affective and emotional impairments in patients with Down syndrome, these parameters are poorly documented in Down syndrome mouse models, including Ts1Cje mice. Here, we conducted comprehensive behavioral analyses, including anxiety-, sociability-, and depression-related tasks, and biochemical analyses of monoamines and their metabolites in Ts1Cje mice. Ts1Cje mice showed enhanced locomotor activity in novel environments and increased social contact with unfamiliar partners when compared with wild-type littermates, but a significantly lower activity in familiar environments. Ts1Cje mice also exhibited some signs of decreased depression like-behavior. Furthermore, Ts1Cje mice showed monoamine abnormalities, including increased extracellular dopamine and serotonin, and enhanced catabolism in the striatum and ventral forebrain. This study constitutes the first report of deviated monoamine metabolism that may help explain the basis for abnormal behaviors, including the environmental stimuli-triggered hyperactivity, increased sociability and decreased depression-like behavior in Ts1Cje mice.",
author = "Atsushi Shimohata and Keiichi Ishihara and Satoko Takai and Hiroyuki Miyamoto and Hiromasa Morishita and Guy Ornthanalai and Matthieu Raveau and Ebrahim, {Abdul Shukkur} and Kenji Amano and Kazuyuki Yamada and Haruhiko Sago and Satoshi Akiba and Nobuko Mataga and Murphy, {Niall P.} and Tsuyoshi Miyakawa and Kazuhiro Yamakawa",
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Shimohata, A, Ishihara, K, Takai, S, Miyamoto, H, Morishita, H, Ornthanalai, G, Raveau, M, Ebrahim, AS, Amano, K, Yamada, K, Sago, H, Akiba, S, Mataga, N, Murphy, NP, Miyakawa, T & Yamakawa, K 2017, 'Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism', Experimental Neurology, 巻. 293, pp. 1-12. https://doi.org/10.1016/j.expneurol.2017.03.009

Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism. / Shimohata, Atsushi; Ishihara, Keiichi; Takai, Satoko; Miyamoto, Hiroyuki; Morishita, Hiromasa; Ornthanalai, Guy; Raveau, Matthieu; Ebrahim, Abdul Shukkur; Amano, Kenji; Yamada, Kazuyuki; Sago, Haruhiko; Akiba, Satoshi; Mataga, Nobuko; Murphy, Niall P.; Miyakawa, Tsuyoshi; Yamakawa, Kazuhiro.

:: Experimental Neurology, 巻 293, 01.07.2017, p. 1-12.

研究成果: Article

TY - JOUR

T1 - Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism

AU - Shimohata, Atsushi

AU - Ishihara, Keiichi

AU - Takai, Satoko

AU - Miyamoto, Hiroyuki

AU - Morishita, Hiromasa

AU - Ornthanalai, Guy

AU - Raveau, Matthieu

AU - Ebrahim, Abdul Shukkur

AU - Amano, Kenji

AU - Yamada, Kazuyuki

AU - Sago, Haruhiko

AU - Akiba, Satoshi

AU - Mataga, Nobuko

AU - Murphy, Niall P.

AU - Miyakawa, Tsuyoshi

AU - Yamakawa, Kazuhiro

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Ts1Cje mice have a segmental trisomy of chromosome 16 that is orthologous to human chromosome 21 and display Down syndrome-like cognitive impairments. Despite the occurrence of affective and emotional impairments in patients with Down syndrome, these parameters are poorly documented in Down syndrome mouse models, including Ts1Cje mice. Here, we conducted comprehensive behavioral analyses, including anxiety-, sociability-, and depression-related tasks, and biochemical analyses of monoamines and their metabolites in Ts1Cje mice. Ts1Cje mice showed enhanced locomotor activity in novel environments and increased social contact with unfamiliar partners when compared with wild-type littermates, but a significantly lower activity in familiar environments. Ts1Cje mice also exhibited some signs of decreased depression like-behavior. Furthermore, Ts1Cje mice showed monoamine abnormalities, including increased extracellular dopamine and serotonin, and enhanced catabolism in the striatum and ventral forebrain. This study constitutes the first report of deviated monoamine metabolism that may help explain the basis for abnormal behaviors, including the environmental stimuli-triggered hyperactivity, increased sociability and decreased depression-like behavior in Ts1Cje mice.

AB - Ts1Cje mice have a segmental trisomy of chromosome 16 that is orthologous to human chromosome 21 and display Down syndrome-like cognitive impairments. Despite the occurrence of affective and emotional impairments in patients with Down syndrome, these parameters are poorly documented in Down syndrome mouse models, including Ts1Cje mice. Here, we conducted comprehensive behavioral analyses, including anxiety-, sociability-, and depression-related tasks, and biochemical analyses of monoamines and their metabolites in Ts1Cje mice. Ts1Cje mice showed enhanced locomotor activity in novel environments and increased social contact with unfamiliar partners when compared with wild-type littermates, but a significantly lower activity in familiar environments. Ts1Cje mice also exhibited some signs of decreased depression like-behavior. Furthermore, Ts1Cje mice showed monoamine abnormalities, including increased extracellular dopamine and serotonin, and enhanced catabolism in the striatum and ventral forebrain. This study constitutes the first report of deviated monoamine metabolism that may help explain the basis for abnormal behaviors, including the environmental stimuli-triggered hyperactivity, increased sociability and decreased depression-like behavior in Ts1Cje mice.

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