TT virus infection among blood donors and patients with non-B, non-C liver diseases in Korea

Tatsunori Nakano, Young Min Park, Masashi Mizokami, Jong Young Choi, Etsuro Orito, Tomoyoshi Ohno, Takanobu Kato, Yutaka Kondo, Yasuhito Tanaka, Hideaki Kato, Tetsuo Kato, Boo Sung Kim

研究成果: ジャーナルへの寄稿学術論文査読

33 被引用数 (Scopus)

抄録

Background/Aims: A novel virus, designated the TT virus (TTV), was isolated from the serum of a patient with posttransfusion hepatitis of unknown etiology, in Japan. Subsequently, TTV was suggested to be a causative agent in a proportion of cases with cryptogenic hepatitis in Japan. This study aimed to elucidate the significance of TTV infection in cases with cryptogenic liver disease in Korea, a neighbor of Japan. Methods: The prevalence of TTV infection was studied in 120 patients with liver diseases, including 85 patients diagnosed as having non-B, non-C liver diseases. As controls, 220 blood donors were also examined. TTV DNA was detected by polymerase chain reaction, and the sequence was analyzed by phylogenetic analysis. Results: Fourteen (14.0%) of 100 accepted blood donors, 23 (19.2%) of 120 rejected blood donors, and 15 (17.6%) of 85 patients with non-B, non- C liver diseases were positive for TTV DNA. The prevalences of TTV infection among these groups were not significantly different. Phylogenetic analysis suggested the existence of four major genotypes of TTV. The proportions of each genotype among patients with non-B, non-C liver diseases were not different from those among accepted blood donors. Conclusions: TTV exists in Korea, but the prevalence among patients with non-B, non-C liver diseases was almost the same as that among blood donors. TTV may not be the main causative agent of cryptogenic liver disease in Korea. The relationship between non-B, non-C liver diseases and TTV genotype remains unclear, although TTV can be classified into four genotypes.

本文言語英語
ページ(範囲)389-393
ページ数5
ジャーナルJournal of Hepatology
30
3
DOI
出版ステータス出版済み - 03-1999
外部発表はい

All Science Journal Classification (ASJC) codes

  • 肝臓学

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