Tumor endothelial cells express high pentraxin 3 levels

Kyoko Hida, Nako Maishi, Taisuke Kawamoto, Kosuke Akiyama, Noritaka Ohga, Yasuhiro Hida, Kenji Yamada, Takayuki Hojo, Hiroshi Kikuchi, Masumi Sato, Chisaho Torii, Nobuo Shinohara, Masanobu Shindoh

研究成果: ジャーナルへの寄稿学術論文査読

10 被引用数 (Scopus)

抄録

It has been described that tumor progression has many similarities to inflammation and wound healing in terms of the signaling processes involved. Among biological responses, angiogenesis, which is necessary for tumor progression and metastasis, is a common hallmark; therefore, tumor blood vessels have been considered as important therapeutic targets in anticancer therapy. We focused on pentraxin 3 (PTX3), which is a marker of cancer-related inflammation, but we found no reports on its expression and function in tumor blood vessels. Here we showed that PTX3 is expressed in mouse and human tumor blood vessels based on immunohistochemical analysis. We found that PTX3 is upregulated in primary mouse and human tumor endothelial cells compared to normal endothelial cells. We also showed that PTX3 plays an important role in the proliferation of the tumor endothelial cells. These results suggest that PTX3 is an important target for antiangiogenic therapy.

本文言語英語
ページ(範囲)687-694
ページ数8
ジャーナルPathology International
66
12
DOI
出版ステータス出版済み - 01-12-2016
外部発表はい

All Science Journal Classification (ASJC) codes

  • 病理学および法医学

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