Twist expression predicts poor clinical outcome of patients with clear cell carcinoma of the ovary

Hiroaki Kajiyama, Satoyo Hosono, Mikio Terauchi, Kiyosumi Shibata, Kazuhiko Ino, Eiko Yamamoto, Seiji Nomura, Akihiro Nawa, Fumitaka Kikkawa

研究成果: Article

25 被引用数 (Scopus)

抄録

Objectives: Twist is a highly conserved basic helix-loop-helix transcription factor that regulates the expression of E-cadherin and promotes the epithelial-mesenchymal transition, which is critical for tumor infiltration. We examined the distribution and expression of this molecule in clear cell carcinoma of the ovary (CCC) to elucidate their clinical significance. Methods: Paraffin sections from CCC tissues (n = 27) were immunostained with Twist antibody and staining intensities were evaluated. Stratified with various clinicopathological factors, overall survival (OS) and progression-free survival (PFS) were evaluated. Results: In the 27 carcinomas, negative Twist immunoexpression was observed in 14 cases (51.9%), and positive immunoexpression in 13 (48.1%). Twist, when categorized into negative versus positive expression, was associated with FIGO stage and peritoneal cytology. In addition, positive Twist expression significantly predicted a poorer OS and PFS compared with negative expression (p < 0.0001). Furthermore, the multivariate analyses revealed that positive Twist expression was an independent prognostic factor for OS and PFS of patients with CCC in this study (p = 0.0077 and 0.0033, respectively). Conclusion: The current findings suggest that the assessment of Twist immunoreactivity may be a useful prognostic indicator and that Twist may play a critical role in the progression of CCC.

本文言語English
ページ(範囲)394-401
ページ数8
ジャーナルOncology
71
5-6
DOI
出版ステータスPublished - 01-10-2007
外部発表はい

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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