Two cases of pollen-food allergy syndrome to soy milk diagnosed by skin prick test, specific serum immunoglobulin E and microarray analysis

Akiko Yagami, Yasuko Inaba, Yuki Kuno, Kayoko Suzuki, Akira Tanaka, Sigrid Sjolander, Hirohisa Saito, Kayoko Matsunaga

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Oral allergy syndrome to soy milk is classified as a phenotype of pollen-food allergy syndrome (PFAS). As causative antigens, Gly m 4 (Bet v 1 homolog, 17 kD) and oleosin (23 kD), have been reported. In this study, we report two cases of PFAS to soy milk. Both cases showed positive reactions to soy milk in skin prick tests (SPT) and to Gly m 4 in specific serum immunoglobulin (Ig)E antibody. When we measured specific serum IgE antibody of soy-related proteins using a new laboratory testing method, microarray analysis, both cases showed a positive reaction for Bet v 1. One case was weakly positive for a soybean protein, β-conglycinin. Other results for reactivity to soy, peanut, cross-reactive carbohydrate determinants and profilin were negative. Based on these results, we diagnosed the two cases as PFAS to Gly m 4. We also performed protein microarray analysis and found it useful as a screening test for immediate allergy, such as PFAS.

本文言語English
ページ(範囲)50-55
ページ数6
ジャーナルJournal of Dermatology
36
1
DOI
出版ステータスPublished - 01-01-2009

All Science Journal Classification (ASJC) codes

  • 皮膚病学

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