Two-stage case-control association study of polymorphisms in rheumatoid arthritis susceptibility genes with schizophrenia

Yuichiro Watanabe, Ayako Nunokawa, Naoshi Kaneko, Tatsuyuki Muratake, Tadao Arinami, Hiroshi Ujike, Toshiya Inada, Nakao Iwata, Hiroshi Kunugi, Masanari Itokawa, Takeshi Otowa, Norio Ozaki, Toshiyuki Someya

研究成果: Article査読

11 被引用数 (Scopus)

抄録

There is strong evidence for a negative association between schizophrenia and rheumatoid arthritis (RA). However, the mechanism for this association is unknown. We hypothesize that these two diseases share susceptibility genes. Recently, extensive studies have identified some RA susceptibility genes, including NFKBIL1, SLC22A4, RUNX1, FCRL3 and PADI4, in the Japanese population. To assess whether polymorphisms in these RA susceptibility genes are implicated in vulnerability to schizophrenia, we conducted a two-stage case-control association study in Japanese subjects. In a screening population of 534 patients and 559 control subjects, we examined eight polymorphisms in RA susceptibility genes and found a potential association of padi4-94 in PADI4 with schizophrenia. However, we could not replicate this association in a confirmatory population of 2126 patients and 2228 control subjects. The results of this study suggest that these polymorphisms in RA susceptibility genes do not contribute to genetic susceptibility to schizophrenia.

本文言語English
ページ(範囲)62-65
ページ数4
ジャーナルJournal of Human Genetics
54
1
DOI
出版ステータスPublished - 01-2009

All Science Journal Classification (ASJC) codes

  • 遺伝学
  • 遺伝学(臨床)

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