TY - JOUR
T1 - Two-Year Clinical Outcome of MitraClip Transcatheter Edge-to-Edge Repair from the J-MITRA Registry Data
AU - J-MITRA Investigators
AU - Imamura, Teruhiko
AU - Nakai, Michikazu
AU - Iwanaga, Yoshitaka
AU - Sumita, Yoko
AU - Tao, Misato
AU - Ohno, Yohei
AU - Hayashida, Kentaro
AU - Morino, Yoshihiro
AU - Seo, Yoshihiro
AU - Saiki, Yoshikatsu
AU - Anzai, Toshihisa
AU - Toda, Koichi
AU - Matsumiya, Goro
AU - Yamamoto, Kazuhiro
AU - Hirata, Kenichi
AU - Fukuda, Keiichi
AU - Yamamoto, Masanori
AU - Koyama, Yutaka
AU - Ando, Kenji
AU - Kozuma, Ken
AU - Naganuma, Toru
AU - Ito, Yoshiaki
AU - Otomo, Tatsushi
AU - Saito, Shigeru
AU - Kinugawa, Koichiro
AU - Ikari, Yuji
AU - Nakajima, Yoshifumi
AU - Akashi, Yoshihiro
AU - Yamazaki, Seiji
AU - Sakamoto, Tomohiro
AU - Hagiwara, Nobuhisa
AU - Kadota, Kazushige
AU - Izumi, Chisato
AU - Tanabe, Kengo
AU - Takamizawa, Itaru
AU - Morikawa, Takao
AU - Miyamoto, Takashi
AU - Yokoi, Yoshiaki
AU - Matoba, Satoaki
AU - Fukuda, Daiju
AU - Hasebe, Naoyuki
AU - Hosokawa, Shinobu
AU - Mizote, Isamu
AU - Sakata, Yashushi
AU - Sakamoto, Hiroki
AU - Okayama, Hideki
AU - Hirokami, Mitsugu
AU - Miura, Tetsuji
AU - Okazaki, Shinya
AU - Ozaki, Yukio
N1 - Publisher Copyright:
© 2024 Japanese Circulation Society. All rights reserved.
PY - 2024/4
Y1 - 2024/4
N2 - Background: The introduction of transcatheter edge-to-edge repair for moderate-to-severe or severe mitral regurgitation (MR) utilizing the MitraClip system became reimbursed and clinically accessible in Japan in April 2018. This study presents the 2-year clinical outcomes of all consecutively treated patients who underwent MitraClip implantation in Japan and were prospectively enrolled in the Japanese Circulation Society-oriented J-MITRA registry. Methods and Results: Analysis encompassed 2,739 consecutive patients enrolled in the J-MITRA registry with informed consent (mean age: 78.3}9.6 years, 1,550 males, STS risk score 11.7}8.9), comprising 1,999 cases of functional MR, 644 of degenerative MR and 96 in a mixed group (DMR and FMR). The acute procedure success rate was 88.9%. After MitraClip implantation, >80% exhibited an MR grade ≤2+ and the trend was sustained over the 2 years. Within this observation period, the mortality rate was 19.3% and the rate of heart failure readmissions was 20.6%. The primary composite endpoint, inclusive of cardiovascular death and heart failure readmission, was significantly higher in patients with functional MR than in with degenerative MR (32.0% vs. 17.5%, P<0.001). Conclusions: The 2-year clinical outcomes after MitraClip implantation were deduced from comprehensive data within an all-Japan registry.
AB - Background: The introduction of transcatheter edge-to-edge repair for moderate-to-severe or severe mitral regurgitation (MR) utilizing the MitraClip system became reimbursed and clinically accessible in Japan in April 2018. This study presents the 2-year clinical outcomes of all consecutively treated patients who underwent MitraClip implantation in Japan and were prospectively enrolled in the Japanese Circulation Society-oriented J-MITRA registry. Methods and Results: Analysis encompassed 2,739 consecutive patients enrolled in the J-MITRA registry with informed consent (mean age: 78.3}9.6 years, 1,550 males, STS risk score 11.7}8.9), comprising 1,999 cases of functional MR, 644 of degenerative MR and 96 in a mixed group (DMR and FMR). The acute procedure success rate was 88.9%. After MitraClip implantation, >80% exhibited an MR grade ≤2+ and the trend was sustained over the 2 years. Within this observation period, the mortality rate was 19.3% and the rate of heart failure readmissions was 20.6%. The primary composite endpoint, inclusive of cardiovascular death and heart failure readmission, was significantly higher in patients with functional MR than in with degenerative MR (32.0% vs. 17.5%, P<0.001). Conclusions: The 2-year clinical outcomes after MitraClip implantation were deduced from comprehensive data within an all-Japan registry.
KW - Heart failure
KW - Hemodynamics
KW - Mitral regurgitation
KW - Registry data
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U2 - 10.1253/circj.CJ-23-0924
DO - 10.1253/circj.CJ-23-0924
M3 - Article
C2 - 38447968
AN - SCOPUS:85189052689
SN - 1346-9843
VL - 88
SP - 539
EP - 548
JO - Circulation Journal
JF - Circulation Journal
IS - 4
ER -