UHRF1, a Regulator of Methylation, as a Diagnostic and Prognostic Marker for Lung Cancer

Daiki Goto; Kazuki Komeda; Natsuki Uwatoko; Moeka Nakashima; Mayu Koike; Kaho Kawai; Yuta Kodama; Ayako Miyazawa; Ichidai Tanaka; Tetsunari Hase; Masahiro Morise; Yoshinori Hasegawa; Tsutomu Kawabe; Mitsuo Sato

doi:10.1080/07357907.2020.1747483

UHRF1, a Regulator of Methylation, as a Diagnostic and Prognostic Marker for Lung Cancer

Daiki Goto
, Kazuki Komeda
, Natsuki Uwatoko
, Moeka Nakashima
, Mayu Koike
, Kaho Kawai
, Yuta Kodama
, Ayako Miyazawa
, Ichidai Tanaka
, Tetsunari Hase
, Masahiro Morise
, Yoshinori Hasegawa
, Tsutomu Kawabe
, Mitsuo Sato

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

6 被引用数 (Scopus)

抄録

We evaluated the value of UHRF1, a regulator of methylation, as a biomarker for lung cancer. UHRF1 is expressed at higher levels in both lung adenocarcinoma (AD) and squamous cell carcinoma (SQ); however, a meta-analysis showed that UHRF1 expression is correlated with worse survival in patients with AD but not in those with SQ. UHRF1 knockdown suppressed the growth of lung cancer cell lines through G1 cell cycle arrest in some cell lines. These results suggest that UHRF1 may server as a diagnostic marker for AD and SQ and as a prognostic marker for AD in lung cancer.

本文言語	英語
ページ（範囲）	240-249
ページ数	10
ジャーナル	Cancer Investigation
巻	38
号	4
DOI	https://doi.org/10.1080/07357907.2020.1747483
出版ステータス	出版済み - 20-04-2020
外部発表	はい

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All Science Journal Classification (ASJC) codes

腫瘍学
癌研究

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10.1080/07357907.2020.1747483

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title = "UHRF1, a Regulator of Methylation, as a Diagnostic and Prognostic Marker for Lung Cancer",

abstract = "We evaluated the value of UHRF1, a regulator of methylation, as a biomarker for lung cancer. UHRF1 is expressed at higher levels in both lung adenocarcinoma (AD) and squamous cell carcinoma (SQ); however, a meta-analysis showed that UHRF1 expression is correlated with worse survival in patients with AD but not in those with SQ. UHRF1 knockdown suppressed the growth of lung cancer cell lines through G1 cell cycle arrest in some cell lines. These results suggest that UHRF1 may server as a diagnostic marker for AD and SQ and as a prognostic marker for AD in lung cancer.",

keywords = "biomarker, Lung cancer, methylation",

author = "Daiki Goto and Kazuki Komeda and Natsuki Uwatoko and Moeka Nakashima and Mayu Koike and Kaho Kawai and Yuta Kodama and Ayako Miyazawa and Ichidai Tanaka and Tetsunari Hase and Masahiro Morise and Yoshinori Hasegawa and Tsutomu Kawabe and Mitsuo Sato",

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doi = "10.1080/07357907.2020.1747483",

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TY - JOUR

T1 - UHRF1, a Regulator of Methylation, as a Diagnostic and Prognostic Marker for Lung Cancer

AU - Goto, Daiki

AU - Komeda, Kazuki

AU - Uwatoko, Natsuki

AU - Nakashima, Moeka

AU - Koike, Mayu

AU - Kawai, Kaho

AU - Kodama, Yuta

AU - Miyazawa, Ayako

AU - Tanaka, Ichidai

AU - Hase, Tetsunari

AU - Morise, Masahiro

AU - Hasegawa, Yoshinori

AU - Kawabe, Tsutomu

AU - Sato, Mitsuo

PY - 2020/4/20

Y1 - 2020/4/20

N2 - We evaluated the value of UHRF1, a regulator of methylation, as a biomarker for lung cancer. UHRF1 is expressed at higher levels in both lung adenocarcinoma (AD) and squamous cell carcinoma (SQ); however, a meta-analysis showed that UHRF1 expression is correlated with worse survival in patients with AD but not in those with SQ. UHRF1 knockdown suppressed the growth of lung cancer cell lines through G1 cell cycle arrest in some cell lines. These results suggest that UHRF1 may server as a diagnostic marker for AD and SQ and as a prognostic marker for AD in lung cancer.

AB - We evaluated the value of UHRF1, a regulator of methylation, as a biomarker for lung cancer. UHRF1 is expressed at higher levels in both lung adenocarcinoma (AD) and squamous cell carcinoma (SQ); however, a meta-analysis showed that UHRF1 expression is correlated with worse survival in patients with AD but not in those with SQ. UHRF1 knockdown suppressed the growth of lung cancer cell lines through G1 cell cycle arrest in some cell lines. These results suggest that UHRF1 may server as a diagnostic marker for AD and SQ and as a prognostic marker for AD in lung cancer.

KW - biomarker

KW - Lung cancer

KW - methylation

UR - https://www.scopus.com/pages/publications/85083657428

UR - https://www.scopus.com/pages/publications/85083657428#tab=citedBy

U2 - 10.1080/07357907.2020.1747483

DO - 10.1080/07357907.2020.1747483

M3 - Article

C2 - 32212938

AN - SCOPUS:85083657428

SN - 0735-7907

VL - 38

SP - 240

EP - 249

JO - Cancer Investigation

JF - Cancer Investigation

IS - 4

ER -

UHRF1, a Regulator of Methylation, as a Diagnostic and Prognostic Marker for Lung Cancer

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