Ultra high resolution pinhole SPECT for small animal study

K. Ogawa, T. Kawade, K. Nakamura, A. Kubo, Takashi Ichihara

研究成果: Article査読

60 被引用数 (Scopus)

抄録

The aim of the study is to develop an ultra high-resolution pinhole SPECT system and analyze the performance by simulations. The pinhole SPECT was conducted with a Toshiba GCA-7200A gamma camera. The diameter of the pinhole was 1 mm. Data were acquired with a 128×128 matrix, and the distance from the center of rotation (COR) to the pinhole was 20 mm [case 1] or 28 mm [case 2J. The data were collected at 4 degree increments over 360 degrees. The Feldkamp method was used for image reconstruction. Before the image reconstruction, we corrected the COR of the pinhole collimator. The imaging voxel was 0.27×0.27×0.27 mm3 [case 1] or 0.4×0.4×.4 mm3 [case 2J. From the experiments with a resolution phantom the spatial resolution (FWHM) was 1.1 mm [case 1] or 1.3 mm [case 2J. The pinhole SPECT was also examined for in vivo imaging for studies of the heart in mice which were injected with Tc-99m-Tetrofosmin intravenously. In the reconstructed image the heart muscle of the mouse was clearly visualized. We also investigated the spatial resolution of the reconstructed image by means of simulations.

本文言語English
ページ(範囲)3122-3126
ページ数5
ジャーナルIEEE Transactions on Nuclear Science
45
6
DOI
出版ステータスPublished - 1998

All Science Journal Classification (ASJC) codes

  • 核物理学および高エネルギー物理学
  • 原子力エネルギーおよび原子力工学
  • 電子工学および電気工学

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