TY - JOUR
T1 - Ultraviolet irradiation-mediated malignant melanoma induction with RET tyrosine kinase activation
AU - Kato, Masashi
AU - Takeda, Kozue
AU - Kawamoto, Yoshiyuki
AU - Hossain, Khaled
AU - Ohgami, Nobutaka
AU - Yanagishita, Takeshi
AU - Ohshima, Yuichiro
AU - Kato, Yoko
AU - Ohgami, Kyoko
AU - Yamamori, Tatsuya
AU - Tateyama, Keisuke
AU - Yamanoshita, Osamu
PY - 2007/1
Y1 - 2007/1
N2 - We previously established a RET-transgenic mouse line (304/B6), in which skin melanosis, benign melanocytic tumors and malignant melanoma spontaneously develop. We found that the activities of RET tyrosine kinase, Erk and c-Jun are definitely upregulated in malignant melanoma in the RET-transgenic mice of line 304/B6. We also established another RET-transgenic mouse line (192), in which skin melanosis and benign melanocytic tumors, but not malignant melanoma, spontaneously develop. Ultraviolet irradiation induced malignant melanoma from benign tumors in the RET-transgenic mice of line 192, and promoted RET tyrosine kinase, Erk and c-Jun activities. These results suggest that the ultraviolet irradiation-mediated enhancement of RET and the activity of its downstream molecules play important roles in malignant melanoma development.
AB - We previously established a RET-transgenic mouse line (304/B6), in which skin melanosis, benign melanocytic tumors and malignant melanoma spontaneously develop. We found that the activities of RET tyrosine kinase, Erk and c-Jun are definitely upregulated in malignant melanoma in the RET-transgenic mice of line 304/B6. We also established another RET-transgenic mouse line (192), in which skin melanosis and benign melanocytic tumors, but not malignant melanoma, spontaneously develop. Ultraviolet irradiation induced malignant melanoma from benign tumors in the RET-transgenic mice of line 192, and promoted RET tyrosine kinase, Erk and c-Jun activities. These results suggest that the ultraviolet irradiation-mediated enhancement of RET and the activity of its downstream molecules play important roles in malignant melanoma development.
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U2 - 10.1265/jjh.62.3
DO - 10.1265/jjh.62.3
M3 - Review article
C2 - 17334087
AN - SCOPUS:34047121203
SN - 0021-5082
VL - 62
SP - 3
EP - 8
JO - Nippon eiseigaku zasshi. Japanese journal of hygiene
JF - Nippon eiseigaku zasshi. Japanese journal of hygiene
IS - 1
ER -