Unexpectedly high rate of de novo constitutional t(11;22) translocations in sperm from normal males

Hiroki Kurahashi; Beverly S. Emanuel

doi:10.1038/ng1001-139

Unexpectedly high rate of de novo constitutional t(11;22) translocations in sperm from normal males

Hiroki Kurahashi
, Beverly S. Emanuel

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

70 被引用数 (Scopus)

抄録

Junction fragments from the constitutional t(11;22)(q23;q11) translocation have previously been cloned and sequenced. Here we report a high incidence of translocation-specific PCR products in sperm DNA from normal individuals. Somatic DNA from these and other normal individuals or from people with chromosomal breakage syndromes do not yield PCR junction fragments, indicating that this translocation originates during meiosis.

本文言語	英語
ページ（範囲）	139-140
ページ数	2
ジャーナル	Nature Genetics
巻	29
号	2
DOI	https://doi.org/10.1038/ng1001-139
出版ステータス	出版済み - 2001
外部発表	はい

All Science Journal Classification (ASJC) codes

遺伝学

文献へのアクセス

10.1038/ng1001-139

他のファイルとリンク

引用スタイル

@article{bd19f90009ab41c9932ed1710f02b29d,

title = "Unexpectedly high rate of de novo constitutional t(11;22) translocations in sperm from normal males",

abstract = "Junction fragments from the constitutional t(11;22)(q23;q11) translocation have previously been cloned and sequenced. Here we report a high incidence of translocation-specific PCR products in sperm DNA from normal individuals. Somatic DNA from these and other normal individuals or from people with chromosomal breakage syndromes do not yield PCR junction fragments, indicating that this translocation originates during meiosis.",

author = "Hiroki Kurahashi and Emanuel, \{Beverly S.\}",

note = "Funding Information: We would like to thank H. Kono, L. Mitchell, R. Wilson and C. Felix for helpful discussions. These studies were supported in part by CA39926 (BSE), HD26979 from the NIH, and funds from the Charles E.H. Upham chair (BSE).",

year = "2001",

doi = "10.1038/ng1001-139",

language = "English",

volume = "29",

pages = "139--140",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "2",

}

TY - JOUR

T1 - Unexpectedly high rate of de novo constitutional t(11;22) translocations in sperm from normal males

AU - Kurahashi, Hiroki

AU - Emanuel, Beverly S.

N1 - Funding Information: We would like to thank H. Kono, L. Mitchell, R. Wilson and C. Felix for helpful discussions. These studies were supported in part by CA39926 (BSE), HD26979 from the NIH, and funds from the Charles E.H. Upham chair (BSE).

PY - 2001

Y1 - 2001

N2 - Junction fragments from the constitutional t(11;22)(q23;q11) translocation have previously been cloned and sequenced. Here we report a high incidence of translocation-specific PCR products in sperm DNA from normal individuals. Somatic DNA from these and other normal individuals or from people with chromosomal breakage syndromes do not yield PCR junction fragments, indicating that this translocation originates during meiosis.

AB - Junction fragments from the constitutional t(11;22)(q23;q11) translocation have previously been cloned and sequenced. Here we report a high incidence of translocation-specific PCR products in sperm DNA from normal individuals. Somatic DNA from these and other normal individuals or from people with chromosomal breakage syndromes do not yield PCR junction fragments, indicating that this translocation originates during meiosis.

UR - https://www.scopus.com/pages/publications/0034790435

UR - https://www.scopus.com/pages/publications/0034790435#tab=citedBy

U2 - 10.1038/ng1001-139

DO - 10.1038/ng1001-139

M3 - Article

C2 - 11586296

AN - SCOPUS:0034790435

SN - 1061-4036

VL - 29

SP - 139

EP - 140

JO - Nature Genetics

JF - Nature Genetics

IS - 2

ER -

Unexpectedly high rate of de novo constitutional t(11;22) translocations in sperm from normal males

抄録

All Science Journal Classification (ASJC) codes

文献へのアクセス

他のファイルとリンク

フィンガープリント

引用スタイル