Unfractionated heparin during the interruption of antiplatelet therapy for non-cardiac surgery after drug-eluting stent implantation

Akihito Tanaka, Hideki Ishii, Yosuke Tatami, Yohei Shibata, Naohiro Osugi, Tomoyuki Ota, Yoshihiro Kawamura, Susumu Suzuki, Yoshimasa Nagao, Tadashi Matsushita, Toyoaki Murohara

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Objective Heparin is not recommended to be administered during the interruption of antiplatelet therapy for non-cardiac surgery. However, there are insufficient data to determine the value. The purpose of the present study was to evaluate the clinical results of the administration of unfractionated heparin during the interruption of antiplatelet therapy in non-cardiac surgery patients who had previously undergone drug-eluting stent (DES) implantation. Methods We retrospectively identified 210 elective non-cardiac surgical procedures that were performed with the administration of unfractionated heparin during interruption of all antiplatelet therapies in patients who had previously undergone DES implantation. Heparin was administered during the perioperative period in accordance with the local practice guideline at out institution. We examined the clinical outcomes within 30 days of surgery. Results The mean number of implanted DESs was 2.1±1.3. No major adverse cardiac events (including cardiac death, definite stent thrombosis, and non-fatal myocardial infarction) occurred in any of the 210 cases within 30 days of surgery. Four of the 210 cases (1.9%) required reoperation for bleeding within 30 days of surgery. Conclusion Our data showed the potential for the perioperative management with unfractionated heparin administration in Japanese patients who had previously undergone DES implantation who required noncardiac surgery with the interruption of all antiplatelet therapies.

本文言語English
ページ(範囲)333-337
ページ数5
ジャーナルInternal Medicine
55
4
DOI
出版ステータスPublished - 15-02-2016
外部発表はい

All Science Journal Classification (ASJC) codes

  • 内科学

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