Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor

Miyuki Nishi, Takeshi Houtani, Yukihiro Noda, Takayoshi Mamiya, Kazuo Sato, Tadashi Doi, Junko Kuno, Hiroshi Takeshima, Toshihide Nukada, Toshitaka Nabeshima, Toshio Yamashita, Tetsuo Noda, Tetsuo Sugimoto

研究成果: ジャーナルへの寄稿学術論文査読

249 被引用数 (Scopus)

抄録

In the G-protein-coupled receptor superfamily, the opioid receptor subfamily is constituted of the three distinct opioid receptors (namely δ-, μ- and κ-subtypes) and the receptor for nociceptin (also designated orphaninFQ). The members of the opioid receptor subfamily were known to mediate a variety of cellular inhibitory effects. The three opioid receptors are known to play central roles in mediating analgesia and many other physiological activities; however, the nociceptin receptor was identified recently and less is known about its physiological roles. Here we report the generation and characterization of mice lacking the nociceptin receptor. The knockout mice showed no significant differences in nociceptive threshold and locomotor activity compared with control mice, but they lost nociceptin-induced behavioral responses. These results indicate that the nociceptin system is not essential for regulation of nociception or locomotor activity. On the other hand, we found insufficient recovery of hearing ability from the adaptation to sound exposure in the mutant mice. Thus, the nociceptin system appears to participate in the regulation of the auditory system.

本文言語英語
ページ(範囲)1858-1864
ページ数7
ジャーナルEMBO Journal
16
8
DOI
出版ステータス出版済み - 15-04-1997
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学一般
  • 分子生物学
  • 生化学、遺伝学、分子生物学一般
  • 免疫学および微生物学一般

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