Uric acid distribution volume calculated by kinetic modeling and extracellular volume predicted by bioimpedance method

Toru Shinzato, Shigeru Nakai, Takahito Ito, Kazuhiko Shibata, Teppei Matsuoka, Shinya Kato, Takeshi Aoki, Ikuto Masakane, Hiroki Hayashi, Naotake Tsuboi, Midori Hasegawa, Daijo Inaguma, Yukio Yuzawa, Susumu Ookawara

研究成果: Article査読

抄録

Background: Several reports indicate that extracellular volume predicted by bioimpedance analysis method is associated with hydration status of hemodialysis patients. Theory: Fundamentally, uric acid does not cross cell membranes by simple diffusion, either by facilitated diffusion or by active transport. In addition, uric acid cannot move through cell membranes in most tissues other than those involved in uric acid excretion. These facts support the interpretation that uric acid distribution volume would therefore correlate with extracellular volume. Methods: We examined correlation between uric acid distribution volume calculated by uric acid mass-balance modeling from regular blood test results and extracellular volume predicted by bioimpedance analysis predicted by BCM (Fresenius Medical Care) in 53 patients. Results: There was a significant correlation between uric acid distribution volume (x) and extracellular volume predicted by bioimpedance analysis (y): y = 0.69x + 3.39, r2 = 0.61, p < 0.0001. Bland–Altman analysis showed systematic error for uric acid distribution volume versus extracellular volume predicted by bioimpedance analysis (mean difference between uric acid distribution volume and extracellular volume predicted by bioimpedance analysis was 0.94 L, 95% confidence interval of difference was −3.29 to 5.17 L). Conclusion: Uric acid distribution volume calculated by uric acid mass-balance modeling from regular blood test results may be an alternative marker of extracellular volume predicted by bioimpedance analysis.

本文言語English
ページ(範囲)701-709
ページ数9
ジャーナルInternational Journal of Artificial Organs
43
11
DOI
出版ステータスPublished - 01-11-2020

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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