Usefulness of combining 123I-FP-CIT-SPECT striatal asymmetry index and cardiac 123I-metaiodobenzylguanidine scintigraphy examinations for diagnosis of parkinsonisms

Yoshiki Niimi, Shinji Ito, Kenichiro Murate, Seiko Hirota, Chika Hikichi, Tomomasa Ishikawa, Toshiki Maeda, Ryunosuke Nagao, Sayuri Shima, Yasuaki Mizutani, Akihiro Ueda, Tatsuro Mutoh

研究成果: Article

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Background Although single-photon emission computerized tomography of the dopamine transporter (DAT-SPECT) is useful for diagnosing parkinsonian syndrome, its applicability toward the early phase of Parkinson's disease remains unknown. Methods We enrolled 32 patients showing parkinsonism with normal cardiac 123I-metaiodobenzylguanidine (MIBG) uptake and abnormal DAT-SPECT findings among 84 consecutive patients with parkinsonism. We divided these patients into two groups (group 1: Parkinson's disease, group 2: corticobasal degeneration, progressive supranuclear palsy, multiple system atrophy), and compared their clinical characteristics, specific binding ratios, and striatal asymmetry indexes on DAT-SPECT examinations. Results The striatal asymmetry indexes were significantly lower in group 1 than in group 2 (p < 0.05), but there were no differences in the specific binding ratios between the two groups. Conclusion The combined use of striatal asymmetry index on DAT-SPECT and cardiac MIBG scintigraphy might offer useful clues for the differential diagnosis of the early phase Parkinson's disease from other parkinsonian syndromes.

ジャーナルJournal of the Neurological Sciences
出版物ステータスPublished - 15-06-2017

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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