Usefulness of combining 123I-FP-CIT-SPECT striatal asymmetry index and cardiac 123I-metaiodobenzylguanidine scintigraphy examinations for diagnosis of parkinsonisms

Yoshiki Niimi, Shinji Ito, Kenichiro Murate, Seiko Hirota, Chika Hikichi, Tomomasa Ishikawa, Toshiki Maeda, Ryunosuke Nagao, Sayuri Shima, Yasuaki Mizutani, Akihiro Ueda, Tatsuro Mutoh

研究成果: Article

9 引用 (Scopus)

抄録

Background Although single-photon emission computerized tomography of the dopamine transporter (DAT-SPECT) is useful for diagnosing parkinsonian syndrome, its applicability toward the early phase of Parkinson's disease remains unknown. Methods We enrolled 32 patients showing parkinsonism with normal cardiac 123I-metaiodobenzylguanidine (MIBG) uptake and abnormal DAT-SPECT findings among 84 consecutive patients with parkinsonism. We divided these patients into two groups (group 1: Parkinson's disease, group 2: corticobasal degeneration, progressive supranuclear palsy, multiple system atrophy), and compared their clinical characteristics, specific binding ratios, and striatal asymmetry indexes on DAT-SPECT examinations. Results The striatal asymmetry indexes were significantly lower in group 1 than in group 2 (p < 0.05), but there were no differences in the specific binding ratios between the two groups. Conclusion The combined use of striatal asymmetry index on DAT-SPECT and cardiac MIBG scintigraphy might offer useful clues for the differential diagnosis of the early phase Parkinson's disease from other parkinsonian syndromes.

元の言語English
ページ(範囲)174-178
ページ数5
ジャーナルJournal of the Neurological Sciences
377
DOI
出版物ステータスPublished - 15-06-2017

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Corpus Striatum
Single-Photon Emission-Computed Tomography
Radionuclide Imaging
Parkinsonian Disorders
Parkinson Disease
Progressive Supranuclear Palsy
Multiple System Atrophy
Dopamine Plasma Membrane Transport Proteins
Differential Diagnosis
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

これを引用

Niimi, Yoshiki ; Ito, Shinji ; Murate, Kenichiro ; Hirota, Seiko ; Hikichi, Chika ; Ishikawa, Tomomasa ; Maeda, Toshiki ; Nagao, Ryunosuke ; Shima, Sayuri ; Mizutani, Yasuaki ; Ueda, Akihiro ; Mutoh, Tatsuro. / Usefulness of combining 123I-FP-CIT-SPECT striatal asymmetry index and cardiac 123I-metaiodobenzylguanidine scintigraphy examinations for diagnosis of parkinsonisms. :: Journal of the Neurological Sciences. 2017 ; 巻 377. pp. 174-178.
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abstract = "Background Although single-photon emission computerized tomography of the dopamine transporter (DAT-SPECT) is useful for diagnosing parkinsonian syndrome, its applicability toward the early phase of Parkinson's disease remains unknown. Methods We enrolled 32 patients showing parkinsonism with normal cardiac 123I-metaiodobenzylguanidine (MIBG) uptake and abnormal DAT-SPECT findings among 84 consecutive patients with parkinsonism. We divided these patients into two groups (group 1: Parkinson's disease, group 2: corticobasal degeneration, progressive supranuclear palsy, multiple system atrophy), and compared their clinical characteristics, specific binding ratios, and striatal asymmetry indexes on DAT-SPECT examinations. Results The striatal asymmetry indexes were significantly lower in group 1 than in group 2 (p < 0.05), but there were no differences in the specific binding ratios between the two groups. Conclusion The combined use of striatal asymmetry index on DAT-SPECT and cardiac MIBG scintigraphy might offer useful clues for the differential diagnosis of the early phase Parkinson's disease from other parkinsonian syndromes.",
author = "Yoshiki Niimi and Shinji Ito and Kenichiro Murate and Seiko Hirota and Chika Hikichi and Tomomasa Ishikawa and Toshiki Maeda and Ryunosuke Nagao and Sayuri Shima and Yasuaki Mizutani and Akihiro Ueda and Tatsuro Mutoh",
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Usefulness of combining 123I-FP-CIT-SPECT striatal asymmetry index and cardiac 123I-metaiodobenzylguanidine scintigraphy examinations for diagnosis of parkinsonisms. / Niimi, Yoshiki; Ito, Shinji; Murate, Kenichiro; Hirota, Seiko; Hikichi, Chika; Ishikawa, Tomomasa; Maeda, Toshiki; Nagao, Ryunosuke; Shima, Sayuri; Mizutani, Yasuaki; Ueda, Akihiro; Mutoh, Tatsuro.

:: Journal of the Neurological Sciences, 巻 377, 15.06.2017, p. 174-178.

研究成果: Article

TY - JOUR

T1 - Usefulness of combining 123I-FP-CIT-SPECT striatal asymmetry index and cardiac 123I-metaiodobenzylguanidine scintigraphy examinations for diagnosis of parkinsonisms

AU - Niimi, Yoshiki

AU - Ito, Shinji

AU - Murate, Kenichiro

AU - Hirota, Seiko

AU - Hikichi, Chika

AU - Ishikawa, Tomomasa

AU - Maeda, Toshiki

AU - Nagao, Ryunosuke

AU - Shima, Sayuri

AU - Mizutani, Yasuaki

AU - Ueda, Akihiro

AU - Mutoh, Tatsuro

PY - 2017/6/15

Y1 - 2017/6/15

N2 - Background Although single-photon emission computerized tomography of the dopamine transporter (DAT-SPECT) is useful for diagnosing parkinsonian syndrome, its applicability toward the early phase of Parkinson's disease remains unknown. Methods We enrolled 32 patients showing parkinsonism with normal cardiac 123I-metaiodobenzylguanidine (MIBG) uptake and abnormal DAT-SPECT findings among 84 consecutive patients with parkinsonism. We divided these patients into two groups (group 1: Parkinson's disease, group 2: corticobasal degeneration, progressive supranuclear palsy, multiple system atrophy), and compared their clinical characteristics, specific binding ratios, and striatal asymmetry indexes on DAT-SPECT examinations. Results The striatal asymmetry indexes were significantly lower in group 1 than in group 2 (p < 0.05), but there were no differences in the specific binding ratios between the two groups. Conclusion The combined use of striatal asymmetry index on DAT-SPECT and cardiac MIBG scintigraphy might offer useful clues for the differential diagnosis of the early phase Parkinson's disease from other parkinsonian syndromes.

AB - Background Although single-photon emission computerized tomography of the dopamine transporter (DAT-SPECT) is useful for diagnosing parkinsonian syndrome, its applicability toward the early phase of Parkinson's disease remains unknown. Methods We enrolled 32 patients showing parkinsonism with normal cardiac 123I-metaiodobenzylguanidine (MIBG) uptake and abnormal DAT-SPECT findings among 84 consecutive patients with parkinsonism. We divided these patients into two groups (group 1: Parkinson's disease, group 2: corticobasal degeneration, progressive supranuclear palsy, multiple system atrophy), and compared their clinical characteristics, specific binding ratios, and striatal asymmetry indexes on DAT-SPECT examinations. Results The striatal asymmetry indexes were significantly lower in group 1 than in group 2 (p < 0.05), but there were no differences in the specific binding ratios between the two groups. Conclusion The combined use of striatal asymmetry index on DAT-SPECT and cardiac MIBG scintigraphy might offer useful clues for the differential diagnosis of the early phase Parkinson's disease from other parkinsonian syndromes.

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