Usefulness of CT-MRI fusion in radiotherapy planning for localized prostate cancer

Hidekazu Tanaka, Shinya Hayashi, Kazuhiro Ohtakara, Hiroaki Hoshi, Takayoshi Iida

研究成果: Article査読

17 被引用数 (Scopus)

抄録

We compared the prostate volumes and rectal doses calculated by CT and CT-MRI fusion, and verified the usefulness of CT-MRI fusion in three-dimensional (3D) radiotherapy planning for localized prostate cancer. Three observers contoured the prostate and rectum of 13 patients with CT and CT-MRI fusion. Prostate delineations were classified into three sub-parts, and the volumes and distances to the rectum (PR distance) were calculated. 3D radiotherapy plans were generated. A dose-volume histogram (DVH) was constructed for the rectum. The intermodality and interobserver variations were assessed. CT-MRI fusion yielded a significantly lower prostate volume by 31%. In the sub-part analysis, the greatest difference was seen for the apical side. The PR distance was significantly extended by 3. 5-mm, and the greatest difference was seen for the basal side. The irradiated rectal volume was reduced in the CT-MRI fusion-based plan. The reduction rates were greater in the relatively high-dose regions. The decrease of the prostate volume and length alteration of the distance between the prostate and rectum were correlated with the decrease of the irradiated rectal volume. The prostate volume delineated by CT-MRI fusion was negatively correlated with the decrease of the irradiated rectal volume. CT showed a tendency towards overestimation of the prostate volume and underestimation of the PR distance as compared to CT-MRI fusion. The rectal dose was significantly reduced in CT-MRI fusion-based plan. Using CT-MRI fusion, especially in cases with a small prostate, the irradiated rectal volume can be reduced, with consequent reduction in rectal complications.

本文言語English
ページ(範囲)782-788
ページ数7
ジャーナルJournal of Radiation Research
52
6
DOI
出版ステータスPublished - 11-2011
外部発表はい

All Science Journal Classification (ASJC) codes

  • 放射線
  • 放射線学、核医学およびイメージング
  • 健康、毒物学および変異誘発

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