Value of Low-Mechanical-Index Contrast-Enhanced Transabdominal Ultrasound for Diagnosis of Pancreatic Cancer: A Meta-analysis

Yasunobu Yamashita, Toshio Shimokawa, Reiko Ashida, Christoph F. Dietrich, Mirko D'Onofrio, Yoshiki Hirooka, Masatoshi Kudo, Hideaki Mori, Atsushi Sofuni, Masayuki Kitano

研究成果: ジャーナルへの寄稿総説査読

2 被引用数 (Scopus)

抄録

The incidence and mortality rates of pancreatic cancer (PC) are increasing. It is important to discriminate PC from the other pancreatic lesions; however, differential diagnosis based on conventional transabdominal ultrasound (US) remains challenging even though US is often the first examination performed. Transabdominal contrast-enhanced ultrasound (CEUS) has high diagnostic accuracy for PC. This meta-analysis aimed to examine the utility of low-mechanical-index CEUS with enhancement for PC diagnosis. A systematic meta-analysis of all potentially relevant articles was performed. Fixed-effects or random-effects models were used to investigate pooled sensitivity, specificity, positive likelihood ratio (LR) and negative LR. The study enrolled 983 patients from nine eligible studies. The pooled estimates of sensitivity and specificity were 92% (95% confidence interval [CI]: 0.89–0.94) and 76% (95% CI: 0.71–0.81), respectively. The diagnostic odds ratio (DOR) for CEUS was high (53.62). The area under the summary receiver operating characteristic curve was 0.95. Funnel plots revealed no publication bias, and there was no significant relationship between the DORs and study characteristics, including continent, type of contrast agent, contrast agent dosage and scan phase. Only number of patients affected diagnostic ability. This meta-analysis indicates that CEUS with enhancement pattern is useful for diagnosis of PC.

本文言語英語
ページ(範囲)3315-3322
ページ数8
ジャーナルUltrasound in Medicine and Biology
47
12
DOI
出版ステータス出版済み - 12-2021

All Science Journal Classification (ASJC) codes

  • 放射線技術および超音波技術
  • 生物理学
  • 音響学および超音波学

フィンガープリント

「Value of Low-Mechanical-Index Contrast-Enhanced Transabdominal Ultrasound for Diagnosis of Pancreatic Cancer: A Meta-analysis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル