抄録
Chronic viral hepatitis is the most important risk factor for progression to hepatocellular carcinoma (HCC). To identify genetic risk factors for progression to HCC in individuals with chronic hepatitis C virus (HCV), we analyzed 467,538 SNPs in 212 Japanese individuals with chronic HCV with HCC and 765 individuals with chronic HCV without HCC. We identified one intronic SNP in the DEPDC5 locus on chromosome 22 associated with HCC risk and confirmed the association using an independent case-control population (710 cases and 1,625 controls). The association was highly significant when we analyzed the stages separately as well as together (rs1012068, P combined = 1.27 × 10 -13, odds ratio = 1.75). The significance level of the association further increased after adjustment for gender, age and platelet count (P = 1.35 × 10-14, odds ratio = 1.96). Our findings suggest that common variants within the DEPDC5 locus affect susceptibility to HCC in Japanese individuals with chronic HCV infection.
本文言語 | 英語 |
---|---|
ページ(範囲) | 797-800 |
ページ数 | 4 |
ジャーナル | Nature Genetics |
巻 | 43 |
号 | 8 |
DOI | |
出版ステータス | 出版済み - 08-2011 |
外部発表 | はい |
All Science Journal Classification (ASJC) codes
- 遺伝学