Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers

Daiki Miki, Hidenori Ochi, C. Nelson Hayes, Hiromi Abe, Tadahiko Yoshima, Hiroshi Aikata, Kenji Ikeda, Hiromitsu Kumada, Joji Toyota, Takashi Morizono, Tatsuhiko Tsunoda, Michiaki Kubo, Yusuke Nakamura, Naoyuki Kamatani, Kazuaki Chayama

研究成果: Article

119 引用 (Scopus)

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Chronic viral hepatitis is the most important risk factor for progression to hepatocellular carcinoma (HCC). To identify genetic risk factors for progression to HCC in individuals with chronic hepatitis C virus (HCV), we analyzed 467,538 SNPs in 212 Japanese individuals with chronic HCV with HCC and 765 individuals with chronic HCV without HCC. We identified one intronic SNP in the DEPDC5 locus on chromosome 22 associated with HCC risk and confirmed the association using an independent case-control population (710 cases and 1,625 controls). The association was highly significant when we analyzed the stages separately as well as together (rs1012068, P combined = 1.27 × 10 -13, odds ratio = 1.75). The significance level of the association further increased after adjustment for gender, age and platelet count (P = 1.35 × 10-14, odds ratio = 1.96). Our findings suggest that common variants within the DEPDC5 locus affect susceptibility to HCC in Japanese individuals with chronic HCV infection.

元の言語English
ページ(範囲)797-800
ページ数4
ジャーナルNature Genetics
43
発行部数8
DOI
出版物ステータスPublished - 01-08-2011

All Science Journal Classification (ASJC) codes

  • Genetics

フィンガープリント Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Miki, D., Ochi, H., Hayes, C. N., Abe, H., Yoshima, T., Aikata, H., Ikeda, K., Kumada, H., Toyota, J., Morizono, T., Tsunoda, T., Kubo, M., Nakamura, Y., Kamatani, N., & Chayama, K. (2011). Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers. Nature Genetics, 43(8), 797-800. https://doi.org/10.1038/ng.876