@article{ec07f5f308414c09ab13b0e8ff9f5f86,
title = "Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations",
abstract = "Lung cancer is the most common cause of death from cancer worldwide, and its incidence is increasing in East Asian and Western countries. To identify genetic factors that modify the risk of lung adenocarcinoma, we conducted a genome-wide association study in a Japanese cohort, with replication in two independent studies in Japanese and Korean individuals, in a total of 2,098 lung adenocarcinoma cases and 11,048 controls. The combined analyses identified two susceptibility loci for lung adenocarcinoma: TERT (rs2736100, combined P = 2.91 × 10 -11, odds ratio (OR) = 1.27) and TP63 (rs10937405, combined P = 7.26 × 10 -12, OR = 1.31). Fine mapping of the region containing TP63 showed that a SNP (rs4488809) in intron 1 of TP63 showed the most significant association. Our results suggest that genetic variation in TP63 may influence susceptibility to lung adenocarcinoma in East Asian populations.",
author = "Daiki Miki and Michiaki Kubo and Atsushi Takahashi and Yoon, {Kyong Ah} and Jeongseon Kim and Lee, {Geon Kook} and Zo, {Jae Ill} and Lee, {Jin Soo} and Naoya Hosono and Takashi Morizono and Tatsuhiko Tsunoda and Naoyuki Kamatani and Kazuaki Chayama and Takashi Takahashi and Johji Inazawa and Yusuke Nakamura and Yataro Daigo",
note = "Funding Information: We thank the staff of the Laboratory for Genotyping Development, Center for Genomic Medicine, RIKEN and the Human Genome Center, Institute of Medical Science, The University of Tokyo for their contribution to SNP genotyping. We also thank members of the BioBank Japan project, the Rotary Club of Osaka-Midosuji District 2660 Rotary International in Japan, and Research Institute and Hospital, National Cancer Center, Korea for supporting our study. Y.D. is a member of the Shiga Cancer Treatment Project supported by Shiga Prefecture (Japan). This work was conducted as a part of the BioBank Japan Project and supported by the Ministry of Education, Culture, Sports, Sciences and Technology of the Japanese government. Management of second replication samples in Korea was supported by grants 0710221 and 0940620 from the National Cancer Center, Korea.",
year = "2010",
month = oct,
doi = "10.1038/ng.667",
language = "English",
volume = "42",
pages = "893--896",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "10",
}
