Vasoactive Intestinal Peptide (VIP) - Induced pulmonary vasodilation mediated by EDRF/NO in isolated perfused rat lungs

S. Iwabuchi, S. Ono, J. Funata, Y. Hoshikawa, S. Ueda, Y. Ashino, T. Tanita, S. Fujimura, K. Koike

研究成果: Article査読

1 被引用数 (Scopus)

抄録

We studied the effects of Vasoactive Intestinal Peptide (VIP) on the pulmonary circulation in isolated perfused rat lungs. VIP caused pulmonary vasodilation in a dose-dependent manner. This effect was inhibited by pretreatment with L-Nω nitro-arginine (L-NNA), a competitive inhibitor of endothelium-derived relaxing factor (EDRF/NO), but not by meclofenamate, a cyclooxygenase inhibitor. Addition of L-arginine, a substrate of EDRF/NO, after treatment with L-NNA reversed VIP-induced pulmonary vasodilation. These results indicate that VIP causes pulmonary vasodilation, and they suggest a role for EDRF/NO in VIP-induced pulmonary vasodilation in isolated rat lungs.

本文言語English
ページ(範囲)262-267
ページ数6
ジャーナルJapanese Journal of Thoracic Diseases
33
3
出版ステータスPublished - 01-01-1995
外部発表はい

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

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