VEGF affects mitochondrial ROS generation in glioma cells and acts as a radioresistance factor

Genro Kashino, Shinko Kobashigawa, Aoki Uchikoshi, Yuki Tamari

研究成果: ジャーナルへの寄稿学術論文査読

抄録

Vascular endothelial growth factor (VEGF) is closely related to angiogenesis. Anticancer therapy by inhibiting VEGF signaling is well established. However, the role of VEGF in cell–cell communication during the response to ionizing radiation is not well understood. Here, we examined the role of VEGF on radiosensitivity of cells. The addition of recombinant VEGF (rVEGF) on cultured rat C6 glioma cells showed a radioprotective effects on X-ray irradiation and reduced oxidative stress. These effects were also observed by endogenous VEGF in supernatant of C6 glioma cells. Reduction of oxidative stress by VEGF is suggested to underlie the radioprotective effects. The mechanism of VEGF-induced reduction of oxidative stress was indicated by a decreased oxygen consumption rate (OCR) in mitochondria. However, the number of DNA double-strand breaks (DSB) immediately after irradiation was not reduced by the treatment with VEGF. These results suggest that VEGF plays a role in cell survival after irradiation by controlling the oxidative condition through mitochondrial function that is independent of the efficiency of DSB induction.

本文言語英語
ページ(範囲)213-220
ページ数8
ジャーナルRadiation and Environmental Biophysics
62
2
DOI
出版ステータス出版済み - 05-2023
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 放射線
  • 環境科学一般

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