Ventricular Repolarization Instability in Patients with a Malignant Form of Ventricular Extrasystoles Originating from the Right Ventricular Outflow Tract

Tomohide Ichikawa, Eiichi Watanabe, Yoshihiro Sobue, Mayumi Yamamoto, Hiroto Harigaya, Kentaro Okuda, Atsushi Kani, Kazuo Kato, Yukio Ozaki

研究成果: Article査読

抄録

Objective: Ventricular extrasystoles (VEs) originating from the right ventricular outflow tract (RVOT) are considered benign, but sometimes lead to sudden cardiac death due to polymorphic ventricular tachycardia or ventricular fibrillation (PVT/VF). Previous case reports suggested that patients with a malignant form of RVOT-VE exhibited a left bundle-branch block morphology and positive deflection in lead I. We assessed the hypothesis that patients with a malignant form of RVOT-VE may have ventricular repolarization instability. Methods and Results: We studied 3 patients with a malignant form of RVOT-VE (age, 34 ± 17 years, 2 males) and compared them to 40 control subjects without structural heart disease. All patients underwent high-resolution digital Holter recording (ela medical) and we determined the maximum value of the beat-to-beat T-wave variability (TAV). The patients with a malignant form of RVOT-VE had a higher maximum value of the TAV than the controls (max TAV: 69 ± 9 μV vs. 20 ± 7 μV, p<0.001). During the follow-up, two males experienced shock deliveries for VF by an implantable cardioverter-defibrillator (ICD). The remaining one female had survived after a radiofrequency Catheter ablation and no ICD was implanted. Conclusions: Our results suggest that patients with a malignant form of RVOT-VE may have a ventricular repolarization instability.

本文言語English
ページ(範囲)190
ページ数1
ジャーナルjournal of arrhythmia
27
DOI
出版ステータスPublished - 2011

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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