Ventricular repolarization lability in children with Kawasaki disease

Marina Kuriki, Masayuki Fujino, Ken Ichi Tanaka, Kayo Horio, Hirofumi Kusuki, Misa Hosoi, Yoshihiko Eryu, Tomochika Kato, Toshio Yamazaki, Tadayoshi Hata

研究成果: ジャーナルへの寄稿学術論文査読

12 被引用数 (Scopus)


Kawasaki disease (KD) is an acute febrile disease of unknown etiology that develops in children and is sometimes accompanied by myocardial dysfunction and systemic vasculitis. However, myocardial repolarization lability has not yet been fully investigated. Thus, the objective of this study was to evaluate myocardial repolarization lability (QT variability index - QTVI) based on the body surface electrocardiograms in the acute and recovery phases. The subjects were 25 children with acute KD who were hospitalized for treatment. An equal number of age-matched healthy children were selected as controls. The RR-intervals and QT-intervals were measured based on a body surface electrocardiogram of 120 consecutive heartbeats to calculate the QTVI. The QTVI values were then compared with the acute and recovery phases. The relationships between blood biochemistry data and QTVI values were also examined. QTVI was significantly decreased from the acute phase to the recovery phase (P < 0.05) and then recovered to the same level as that of the control. QTVI in the acute phase showed a significant positive relationship with body temperature and C-reactive protein (P <0.05). QTVI was high in the acute phase and was correlated with an inflammatory reaction and became normalized during the recovery phase.

ジャーナルPediatric Cardiology
出版ステータス出版済み - 04-2011

All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康
  • 循環器および心血管医学


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