Viral DNA Loads in Various Blood Components of Patients with Epstein-Barr Virus-Positive T-Cell/Natural Killer Cell Lymphoproliferative Diseases

Jun Ichi Kawada; Yasuko Kamiya; Akihisa Sawada; Keiji Iwatsuki; Koji Izutsu; Yuka Torii; Hiroshi Kimura; Yoshinori Ito

doi:10.1093/infdis/jiz315

Viral DNA Loads in Various Blood Components of Patients with Epstein-Barr Virus-Positive T-Cell/Natural Killer Cell Lymphoproliferative Diseases

Jun Ichi Kawada, Yasuko Kamiya, Akihisa Sawada, Keiji Iwatsuki, Koji Izutsu, Yuka Torii, Hiroshi Kimura, Yoshinori Ito

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

14 被引用数 (Scopus)

抄録

To evaluate diagnostic values for Epstein-Barr virus (EBV) DNA loads in different blood components of patients with EBV-positive T-cell/natural killer cell lymphoproliferative diseases, EBV DNA loads were compared among disease categories in each blood component from 59 patients. Plasma viral loads were significantly higher in "active" disease in chronic active EBV infection. EBV DNA was not detected in the plasma from 7 patients in whom EBV DNA was detected in peripheral blood mononuclear cells and whole blood. Diagnostic cutoff values for whole blood EBV DNA loads of patients with chronic active EBV infection compared with those of infectious mononucleosis was 10^4.2 (15 800) IU/mL.

本文言語	英語
ページ（範囲）	1307-1311
ページ数	5
ジャーナル	Journal of Infectious Diseases
巻	220
号	8
DOI	https://doi.org/10.1093/infdis/jiz315
出版ステータス	出版済み - 13-09-2019
外部発表	はい

All Science Journal Classification (ASJC) codes

免疫アレルギー学
感染症

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

文献へのアクセス

10.1093/infdis/jiz315

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引用スタイル

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abstract = "To evaluate diagnostic values for Epstein-Barr virus (EBV) DNA loads in different blood components of patients with EBV-positive T-cell/natural killer cell lymphoproliferative diseases, EBV DNA loads were compared among disease categories in each blood component from 59 patients. Plasma viral loads were significantly higher in {"}active{"} disease in chronic active EBV infection. EBV DNA was not detected in the plasma from 7 patients in whom EBV DNA was detected in peripheral blood mononuclear cells and whole blood. Diagnostic cutoff values for whole blood EBV DNA loads of patients with chronic active EBV infection compared with those of infectious mononucleosis was 104.2 (15 800) IU/mL.",

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AU - Iwatsuki, Keiji

AU - Izutsu, Koji

AU - Torii, Yuka

AU - Kimura, Hiroshi

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