Volume of Amygdala Subregions and Plasma Levels of Brain-Derived Neurotrophic Factor and Cortisol in Patients with s/s Genotype of Serotonin Transporter Gene Polymorphism of First-Episode and Drug-Naive Major Depressive Disorder: An Exploratory Study

Naomichi Okamoto, Keita Watanabe, Hirofumi Tesen, Atsuko Ikenouchi, Ryohei Igata, Yuki Konishi, Tomoya Natsuyama, Rintaro Fujii, Shingo Kakeda, Taro Kishi, Nakao Iwata, Reiji Yoshimura

研究成果: ジャーナルへの寄稿学術論文査読

1 被引用数 (Scopus)

抄録

The amygdala is a prominent region of the brain that plays a critical role in the pathophysiology of major depressive disorder (MDD). The amygdala is formed from a collection of interconnected substructures (nuclei) that relay signals from multiple brain areas, which suggests that the amygdala has different functions depending on its subregion. There are two main alleles of serotonin transporter gene polymorphism (5-HTTLPR): a 44-bp insertion (l-allele) or deletion (s-allele). The transcriptional activity of the l-allele of the gene is twice that of the s-allele. The present study aimed to investigate the association between the volume of the whole amygdala and subregions of the amygdala in 25 first-episode and drug-naive patients with MDD and 46 healthy controls (HCs) with the s/s genotype of 5-HTTLPR and plasma levels of brain-derived neurotrophic factor (BDNF) or cortisol. No significant difference was observed in the amygdala total and subregion volumes between the HC and MDD groups. No significant difference was found in the plasma levels of BDNF and cortisol between the two groups. In addition, no correlations were found between the total and subregion amygdala volume and plasma levels of cortisol or BDNF.

本文言語英語
ページ(範囲)378-390
ページ数13
ジャーナルNeurology International
14
2
DOI
出版ステータス出版済み - 06-2022

All Science Journal Classification (ASJC) codes

  • 臨床神経学

フィンガープリント

「Volume of Amygdala Subregions and Plasma Levels of Brain-Derived Neurotrophic Factor and Cortisol in Patients with s/s Genotype of Serotonin Transporter Gene Polymorphism of First-Episode and Drug-Naive Major Depressive Disorder: An Exploratory Study」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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