Volumetric analysis of coronary plaque characterization in patients with metabolic syndrome using 64-slice multi-detector computed tomography

Kosuke Arai, Hideki Ishii, Tetsuya Amano, Tadayuki Uetani, Michio Nanki, Nobuyuki Marui, Masataka Kato, Kiminobu Yokoi, Hirohiko Ando, Soichiro Kumagai, Ken Harada, Daiji Yoshikawa, Satoru Ohshima, Tatsuaki Matsubara, Toyoaki Murohara

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Background: Metabolic syndrome (MetS) is associated with adverse cardiovascular events and mortality, where acute coronary syndrome significantly impacts on mortality and morbidity. In contrast, evidences have accumulated that the lipid-rich plaque might play a critical role in acute coronary syndrome. Methods and Results: The study population consisted of 94 patients with suspected angina pectoris who underwent multi-detector computed tomography (MDCT). Of those, we identified 41 with MetS. In MDCT analysis, low-density plaque volume (LDPV) (42±28 vs 24±18 mm3, P=0.0003), moderate-density plaque volume (105±41 vs 82±33 mm3, P=0.003), total plaque volume (164±70 vs 118±59 mm3, P=0.0008) and %LDPV (24.2±10.0 vs 18.3±7.1%, P=0.01) were significantly increased in the MetS group compared to the non-MetS group. Multivariate linear regression analysis after adjusting for confounding variables revealed that MetS was significantly correlated with an increase in %LDPV (β=0.48, P=0.0001). Multivariate logistic regression analysis for lipid-rich plaque after adjusting for confounding variables indicated that MetS was significantly associated with lipid-rich plaque (odds ratio: 5.99, 95% confidence intervals: 1.94-18.6, P=0.002). Conclusions: Patients with MetS were strongly related to having a lipid-rich composition in their coronary plaque, as detected by MDCT.

本文言語English
ページ(範囲)2146-2151
ページ数6
ジャーナルCirculation Journal
74
10
DOI
出版ステータスPublished - 2010
外部発表はい

All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学

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