TY - JOUR
T1 - Vomeroglandin/CRP-ductin is strongly expressed in the glands associated with the mouse vomeronasal organ
T2 - Identification and characterization of mouse vomeroglandin
AU - Matsushita, Fumio
AU - Miyawaki, Atsushi
AU - Mikoshiba, Katsuhiko
N1 - Funding Information:
We would like to thank Prof. R. Hayashi for his kind effort to make possible F.M.’s study under K.M. We wish to thank Dr. T. Furuichi for helpful discussions and Dr. Yasutomi for technical assistance with continuous encouragement. We are also grateful to Mr. T. Kojima (Leica Corp.) for technical assistance in photomicroscopy under dark-field illumination.
PY - 2000/2/16
Y1 - 2000/2/16
N2 - Vomeroglandin, a subform of mouse CRP-ductin, is a protein strongly expressed in the glands of mouse vomeronasal system. Both the proteins contain several of scavenger receptor cysteine-rich and CUB domains and one ZP domain. This domain arrangement is similar to those of rat Ebnerin, human DMBT1, and rabbit hensin. In situ hybridization analysis shows strong expression of vomeroglandin mRNA in the glands of vomeronasal system. Immunological analyses detect both membrane-bound and secreted forms of vomeroglandin. The secreted protein seems to be localized in the lumen of the vomeronasal organ, playing a certain role in the pheromone perception. (C) 2000 Academic Press.
AB - Vomeroglandin, a subform of mouse CRP-ductin, is a protein strongly expressed in the glands of mouse vomeronasal system. Both the proteins contain several of scavenger receptor cysteine-rich and CUB domains and one ZP domain. This domain arrangement is similar to those of rat Ebnerin, human DMBT1, and rabbit hensin. In situ hybridization analysis shows strong expression of vomeroglandin mRNA in the glands of vomeronasal system. Immunological analyses detect both membrane-bound and secreted forms of vomeroglandin. The secreted protein seems to be localized in the lumen of the vomeronasal organ, playing a certain role in the pheromone perception. (C) 2000 Academic Press.
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U2 - 10.1006/bbrc.2000.2104
DO - 10.1006/bbrc.2000.2104
M3 - Article
C2 - 10679193
AN - SCOPUS:0034673375
SN - 0006-291X
VL - 268
SP - 275
EP - 281
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -