Voriconazole-responsive disseminated nodular lesions on spinal MRI

Seiko Hirota, Shinji Ito, Takao Fukui, Kenichiro Murate, Sayuri Shima, Madoka Kizawa, Akihiro Ueda, Kunihiko Asakura, Tatsuro Mutoh

研究成果: Article


A 74-year-old woman was hospitalized due to dysuria, weakness and dysesthesia of the lower extremities. She was in an immunosuppressed state following the administration of methylprednisolone therapy for idiopathic interstitial pneumonia. Cerebrospinal fluid and blood cultures were negative, and no infectious biomarkers were found. A gadolinium (Gd)-enhanced T1-weighted image of magnetic resonance imaging (MRI) revealed disseminated nodular lesions along the spinal cord. We suspected a diagnosis of seronegative deep mycosis and initiated anti-fungal therapy with voriconazole, which subsequently alleviated all of the patient’s symptoms and MRI findings. Therefore, the presence of Gd-enhanced disseminated nodules on spinal MRI may be a good marker of deep meningeal mycosis.

ジャーナルInternal Medicine
出版物ステータスPublished - 15-01-2015


All Science Journal Classification (ASJC) codes

  • Internal Medicine


Hirota, S., Ito, S., Fukui, T., Murate, K., Shima, S., Kizawa, M., Ueda, A., Asakura, K., & Mutoh, T. (2015). Voriconazole-responsive disseminated nodular lesions on spinal MRI. Internal Medicine, 54(2), 215-218. https://doi.org/10.2169/internalmedicine.54.3148