@article{6d98ac9e4b144c4a9e20a55c83ef7411,
title = "WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis",
abstract = "Identification of physiological substrates for Cdc2/cyclin B is crucial for understanding the functional link between mitotic events and Cdc2/cyclin B activation. A human homologue of the Drosophila warts tumor suppressor, termed WARTS, is a serine/threonine kinase and a dynamic component of the mitotic apparatus. We have found that Cdc2/cyclin B forms a complex with a fraction of WARTS in the centrosome and phosphorylates the Ser613 site of WARTS during mitosis. Immunocytochemical analysis has shown that the S613-phosphorylated WARTS appears in the spindle poles at prometaphase and disappears at telophase. Our findings suggest that Cdc/cyclin B regulates functions of WARTS on the mitotic apparatus.",
author = "Tetsuro Morisaki and Toru Hirota and Iida, \{Shin ichi\} and Tomotoshi Marumoto and Toshihiro Hara and Yasuyuki Nishiyama and Michio Kawasuzi and Takehisa Hiraoka and Tatsuyuki Mimori and Norie Araki and Ichiro Izawa and Masaki Inagaki and Hideyuki Saya",
note = "Funding Information: We thank Dr. H. Goto for valuable suggestions; Dr. J. Moon for editing the manuscript; and Y. Fukushima for secretarial assistance. We are also grateful to members of the Gene Technology Center in Kumamoto University for their important contributions to the experiments. This work was supported by a grant for Cancer Research from the Japanese Ministry of Education, Science, Sports and Culture (H.S.), and the {\textquoteleft}Research for the Future{\textquoteright} program (H.S.) of the Japan Society for the Promotion of Science.",
year = "2002",
month = oct,
day = "9",
doi = "10.1016/S0014-5793(02)03360-4",
language = "English",
volume = "529",
pages = "319--324",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "John Wiley and Sons Inc.",
number = "2-3",
}