抄録
It has long been debated whether watershed infarcts are caused by hemodynamic or embolic mechanisms. In the present study, we investigated microembolic roles in the pathogenesis of watershed infarcts by examining MRI in a macaque monkey model of multiple microinfarcts. 50μm microbeads were injected into each internal carotid artery twice with a month interval. Monkeys (n=4) injected with 2250-2800 microbeads per unilateral side showed both cortical and internal watershed infarcts in the acute phase and atrophic changes with microbleeds in the chronic phase. These results suggest embolic pathogenesis can contribute to the genesis of both cortical and internal watershed infarcts in primates.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 80-83 |
| ページ数 | 4 |
| ジャーナル | Neuroscience Letters |
| 巻 | 499 |
| 発行部数 | 2 |
| DOI | |
| 出版物ステータス | Published - 20-07-2011 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
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Watershed infarcts in a multiple microembolic model of monkey. / Maki, Takakuni; Wakita, Hideaki; Mase, Mitsuhito; Itagaki, Iori; Saito, Naoyuki; Ono, Fumiko; Adachi, Kayo; Ito, Hidefumi; Takahashi, Ryosuke; Ihara, Masafumi; Tomimoto, Hidekazu.
：: Neuroscience Letters, 巻 499, 番号 2, 20.07.2011, p. 80-83.研究成果: Article
TY - JOUR
T1 - Watershed infarcts in a multiple microembolic model of monkey
AU - Maki, Takakuni
AU - Wakita, Hideaki
AU - Mase, Mitsuhito
AU - Itagaki, Iori
AU - Saito, Naoyuki
AU - Ono, Fumiko
AU - Adachi, Kayo
AU - Ito, Hidefumi
AU - Takahashi, Ryosuke
AU - Ihara, Masafumi
AU - Tomimoto, Hidekazu
PY - 2011/7/20
Y1 - 2011/7/20
N2 - It has long been debated whether watershed infarcts are caused by hemodynamic or embolic mechanisms. In the present study, we investigated microembolic roles in the pathogenesis of watershed infarcts by examining MRI in a macaque monkey model of multiple microinfarcts. 50μm microbeads were injected into each internal carotid artery twice with a month interval. Monkeys (n=4) injected with 2250-2800 microbeads per unilateral side showed both cortical and internal watershed infarcts in the acute phase and atrophic changes with microbleeds in the chronic phase. These results suggest embolic pathogenesis can contribute to the genesis of both cortical and internal watershed infarcts in primates.
AB - It has long been debated whether watershed infarcts are caused by hemodynamic or embolic mechanisms. In the present study, we investigated microembolic roles in the pathogenesis of watershed infarcts by examining MRI in a macaque monkey model of multiple microinfarcts. 50μm microbeads were injected into each internal carotid artery twice with a month interval. Monkeys (n=4) injected with 2250-2800 microbeads per unilateral side showed both cortical and internal watershed infarcts in the acute phase and atrophic changes with microbleeds in the chronic phase. These results suggest embolic pathogenesis can contribute to the genesis of both cortical and internal watershed infarcts in primates.
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UR - http://www.scopus.com/inward/citedby.url?scp=79959373837&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2011.05.036
DO - 10.1016/j.neulet.2011.05.036
M3 - Article
C2 - 21640789
AN - SCOPUS:79959373837
VL - 499
SP - 80
EP - 83
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2
ER -