Watershed infarcts in a multiple microembolic model of monkey

Takakuni Maki; Hideaki Wakita; Mitsuhito Mase; Iori Itagaki; Naoyuki Saito; Fumiko Ono; Kayo Adachi; Hidefumi Ito; Ryosuke Takahashi; Masafumi Ihara; Hidekazu Tomimoto

doi:10.1016/j.neulet.2011.05.036

Watershed infarcts in a multiple microembolic model of monkey

Takakuni Maki, Hideaki Wakita, Mitsuhito Mase, Iori Itagaki, Naoyuki Saito, Fumiko Ono, Kayo Adachi, Hidefumi Ito, Ryosuke Takahashi, Masafumi Ihara, Hidekazu Tomimoto

呼吸器内科学Ⅱ

研究成果: Article

9 被引用数 (Scopus)

抄録

It has long been debated whether watershed infarcts are caused by hemodynamic or embolic mechanisms. In the present study, we investigated microembolic roles in the pathogenesis of watershed infarcts by examining MRI in a macaque monkey model of multiple microinfarcts. 50μm microbeads were injected into each internal carotid artery twice with a month interval. Monkeys (n=4) injected with 2250-2800 microbeads per unilateral side showed both cortical and internal watershed infarcts in the acute phase and atrophic changes with microbleeds in the chronic phase. These results suggest embolic pathogenesis can contribute to the genesis of both cortical and internal watershed infarcts in primates.

本文言語	English
ページ（範囲）	80-83
ページ数	4
ジャーナル	Neuroscience Letters
巻	499
号	2
DOI	https://doi.org/10.1016/j.neulet.2011.05.036
出版ステータス	Published - 20-07-2011

All Science Journal Classification (ASJC) codes

Neuroscience(all)

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10.1016/j.neulet.2011.05.036

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引用スタイル

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AU - Saito, Naoyuki

AU - Ono, Fumiko

AU - Adachi, Kayo

AU - Ito, Hidefumi

AU - Takahashi, Ryosuke

AU - Ihara, Masafumi

AU - Tomimoto, Hidekazu

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