White matter lesions and alteration of vascular cell composition in the brain of spontaneously hypertensive rats

Jin Xi Lin, Hidekazu Tomimoto, Ichiro Akiguchi, Hideaki Wakita, Hiroshi Shibasaki, Ryoichi Horie

研究成果: Article

31 引用 (Scopus)

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There have been few studies on the white matter lesions of spontaneously hypertensive rats (SHR). From the point of view of hypertension and arteriosclerosis, white matter lesions were examined in SHR and stroke-prone SHR (SHRSP), and were then compared with Wistar-Kyoto (WKY) rats. The vasculopathy was analyzed by morphometric immunohistochemistry for collagen and smooth muscle actin. Both SHR and SHRSP had hypertension at ≥ 12 weeks of age, and the latter developed severe white matter lesions at 20 weeks. Immunohistochemistry revealed proliferation of microglia in the white matter and an increase in smooth muscle actin in the vessels of SHRSP compared with the WKY rats and SHR, but there were no changes in the collagen. These results indicate a role of hypertension in the pathogenesis of white matter lesions. However, genetic difference may also be responsible since SHR and SHRSP showed similar hypertension.

元の言語English
ページ(範囲)1835-1839
ページ数5
ジャーナルNeuroreport
12
発行部数9
DOI
出版物ステータスPublished - 03-07-2001

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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