Whole-brain perfusion CT performed with a prototype 256-detector row CT system: Initial experience

Kazuhiro Murayama, Kazuhiro Katada, Masato Nakane, Hiroshi Toyama, Hirofumi Anno, Motoharu Hayakawa, Diego San Millan Ruiz, Kieran J. Murphy

研究成果: Article

66 引用 (Scopus)

抄録

Purpose: To preliminarily evaluate the feasibility and potential diagnostic utility of whole-brain perfusion computed tomography (CT) performed with a prototype 256-detector row CT system over an extended range covering the entire brain to assess ischemic cerebrovascular disease. Materials and Methods: Institutional review board approval and informed consent were obtained. Eleven cases in 10 subjects (six men, four women; mean age, 64.3 years) with intra- or extracranial stenosis were retrospectively evaluated with whole-brain perfusion CT. Three readers independently evaluated per- fusion CT data. The diagnostic performance of perfusion CT was visually evaluated with a three-point scale used to assess three factors. Differences between four axial perfusion CT images obtained at the basal ganglia level (hereafter, four-section images) and whole-brain perfusion CT images were assessed with the paired t test. In four subjects, the interval between perfusion CT and single photon emission computed tomography (SPECT) was 1-17 days (mean, 10.3 days). Correlation between perfusion CT findings and SPECT findings was assessed with the Spearman correlation coefficient. Results: Three-dimensional perfusion CT images and axial, coronal, and sagittal whole-brain perfusion CT images were displayed, and the extent of ischemia was assessed. Mean visual evaluation scores were significantly higher for whole-brain images than for four-section images (4.27 ± 0.76 [standard deviation] vs 2.55 ± 0.87). The cerebral blood flow ratios of the ischemic lesions relative to normal regions scanned with perfusion CT (x) and SPECT (y) showed a significant positive correlation (R 2 = 0.76, y = 0.44x + 0.37, P < .001). Conclusion: Perfusion CT performed with a 256-detector row CT system can be used to assess the entire brain with administration of one contrast medium bolus. Thus, ischemic regions can be identified with one examination, which has the potential to improve diagnostic utility.

元の言語English
ページ(範囲)202-211
ページ数10
ジャーナルRadiology
250
発行部数1
DOI
出版物ステータスPublished - 01-01-2009

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Perfusion
Tomography
Brain
Cerebrovascular Circulation
Cerebrovascular Disorders
Research Ethics Committees
Basal Ganglia
Informed Consent
Contrast Media
Pathologic Constriction
Ischemia
Single Photon Emission Computed Tomography Computed Tomography

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

これを引用

Murayama, Kazuhiro ; Katada, Kazuhiro ; Nakane, Masato ; Toyama, Hiroshi ; Anno, Hirofumi ; Hayakawa, Motoharu ; Ruiz, Diego San Millan ; Murphy, Kieran J. / Whole-brain perfusion CT performed with a prototype 256-detector row CT system : Initial experience. :: Radiology. 2009 ; 巻 250, 番号 1. pp. 202-211.
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abstract = "Purpose: To preliminarily evaluate the feasibility and potential diagnostic utility of whole-brain perfusion computed tomography (CT) performed with a prototype 256-detector row CT system over an extended range covering the entire brain to assess ischemic cerebrovascular disease. Materials and Methods: Institutional review board approval and informed consent were obtained. Eleven cases in 10 subjects (six men, four women; mean age, 64.3 years) with intra- or extracranial stenosis were retrospectively evaluated with whole-brain perfusion CT. Three readers independently evaluated per- fusion CT data. The diagnostic performance of perfusion CT was visually evaluated with a three-point scale used to assess three factors. Differences between four axial perfusion CT images obtained at the basal ganglia level (hereafter, four-section images) and whole-brain perfusion CT images were assessed with the paired t test. In four subjects, the interval between perfusion CT and single photon emission computed tomography (SPECT) was 1-17 days (mean, 10.3 days). Correlation between perfusion CT findings and SPECT findings was assessed with the Spearman correlation coefficient. Results: Three-dimensional perfusion CT images and axial, coronal, and sagittal whole-brain perfusion CT images were displayed, and the extent of ischemia was assessed. Mean visual evaluation scores were significantly higher for whole-brain images than for four-section images (4.27 ± 0.76 [standard deviation] vs 2.55 ± 0.87). The cerebral blood flow ratios of the ischemic lesions relative to normal regions scanned with perfusion CT (x) and SPECT (y) showed a significant positive correlation (R 2 = 0.76, y = 0.44x + 0.37, P < .001). Conclusion: Perfusion CT performed with a 256-detector row CT system can be used to assess the entire brain with administration of one contrast medium bolus. Thus, ischemic regions can be identified with one examination, which has the potential to improve diagnostic utility.",
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Murayama, K, Katada, K, Nakane, M, Toyama, H, Anno, H, Hayakawa, M, Ruiz, DSM & Murphy, KJ 2009, 'Whole-brain perfusion CT performed with a prototype 256-detector row CT system: Initial experience', Radiology, 巻. 250, 番号 1, pp. 202-211. https://doi.org/10.1148/radiol.2501071809

Whole-brain perfusion CT performed with a prototype 256-detector row CT system : Initial experience. / Murayama, Kazuhiro; Katada, Kazuhiro; Nakane, Masato; Toyama, Hiroshi; Anno, Hirofumi; Hayakawa, Motoharu; Ruiz, Diego San Millan; Murphy, Kieran J.

:: Radiology, 巻 250, 番号 1, 01.01.2009, p. 202-211.

研究成果: Article

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T1 - Whole-brain perfusion CT performed with a prototype 256-detector row CT system

T2 - Initial experience

AU - Murayama, Kazuhiro

AU - Katada, Kazuhiro

AU - Nakane, Masato

AU - Toyama, Hiroshi

AU - Anno, Hirofumi

AU - Hayakawa, Motoharu

AU - Ruiz, Diego San Millan

AU - Murphy, Kieran J.

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N2 - Purpose: To preliminarily evaluate the feasibility and potential diagnostic utility of whole-brain perfusion computed tomography (CT) performed with a prototype 256-detector row CT system over an extended range covering the entire brain to assess ischemic cerebrovascular disease. Materials and Methods: Institutional review board approval and informed consent were obtained. Eleven cases in 10 subjects (six men, four women; mean age, 64.3 years) with intra- or extracranial stenosis were retrospectively evaluated with whole-brain perfusion CT. Three readers independently evaluated per- fusion CT data. The diagnostic performance of perfusion CT was visually evaluated with a three-point scale used to assess three factors. Differences between four axial perfusion CT images obtained at the basal ganglia level (hereafter, four-section images) and whole-brain perfusion CT images were assessed with the paired t test. In four subjects, the interval between perfusion CT and single photon emission computed tomography (SPECT) was 1-17 days (mean, 10.3 days). Correlation between perfusion CT findings and SPECT findings was assessed with the Spearman correlation coefficient. Results: Three-dimensional perfusion CT images and axial, coronal, and sagittal whole-brain perfusion CT images were displayed, and the extent of ischemia was assessed. Mean visual evaluation scores were significantly higher for whole-brain images than for four-section images (4.27 ± 0.76 [standard deviation] vs 2.55 ± 0.87). The cerebral blood flow ratios of the ischemic lesions relative to normal regions scanned with perfusion CT (x) and SPECT (y) showed a significant positive correlation (R 2 = 0.76, y = 0.44x + 0.37, P < .001). Conclusion: Perfusion CT performed with a 256-detector row CT system can be used to assess the entire brain with administration of one contrast medium bolus. Thus, ischemic regions can be identified with one examination, which has the potential to improve diagnostic utility.

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